- Taylor Kitsch
- Sam
- Jennette McCurdy
- Sue
- James Woods
- Victor
- Carla Gugino
- Catherine
- Tom Green
- Okra
- Jon Heder
- Wilmer
- Jason Mewes
- Kit
- Jason Kravits
- Oscar
- Jim Breuer
- Mr. Glump
- Lex Lang
- OX King
- Steve Kramer
- Zang
- Meira Blinkoff
- Minitar
- Asher Blinkoff
- Minitar
- Julian Zane
- Minitar
- Dave B. Mitchell
- Police / Boxer (voice) (as Dave Mitchell)
- Alicyn Packard
- Cancan Robot
- Rena Strober
- Computer Voice
- Richard Epcar
- Captain Black
- Eva Bella
- Young Sue
- Zachary Alexander Rice
- Young Sam
- Steve Prince
- Clerk
- Cassandra Lee Morris
- Additional Voices
- Doug Erholtz
- Additional Voices
- Ezra Weisz
- Additional Voices
- Sandy Fox
- Additional Voices
- Richard Cansino
- Additional Voices
- Rebecca Forstadt
- Additional Voices
- Ellyn Stern
- Additional Voices
- Kaiji Tang
- Additional Voices
- Nikki Ghisel
- Additional Voices
- Phil Morris
- Additional Voices
- Rick Federman
- Additional Voices
- Geoffrey Cantor
- Additional Voices
- Michelle Withfield
- Additional Voices
- Phil LaMarr
- Additional Voices