- Denis Leary
- Self
- Barenaked Ladies
- Themselves
- Steve Bridges
- President George W. Bush
- Carmen Electra
- Self
- Chris Elliott
- Self
- Charlie Murphy
- Self
- Bill Nunn
- Self
- William Shatner
- Self
- Morgan Spurlock
- Self
- Billy Dee Williams
- Self
- Chris Phillips
- Denis Leary Band / Various (segment "It's Jihad Farley Towne")
- Adam Roth
- Denis Leary Band
- Charlie Roth
- Denis Leary Band
- Bobby Tisdale
- Nuns Gone Wild Host
- Zak Orth
- Nuns Gone Wild Host
- Matt Ballard
- (as Matthew Ballard)
- Jodie Bentley
- Nun
- Meggan Lennon
- Nun
- Andrea Rosen
- Nun
- Ashley Paige Albert
- Various (segment "It's Jihad Farley Towne")
- Jake T. Austin
- Various (segment "It's Jihad Farley Towne")
- Christine Walters
- Linus, Sally, Marcie (segment "It's Jihad Farley Towne")
- Emily Bindiger
- The Accidentals Choir Member #1
- Dennis Deal
- The Accidentals Choir Member #2
- Margaret Dorn
- The Accidentals Choir Member #3
- Stewart Gregory
- The Accidentals Choir Member #4
- Bill Mitchell
- The Accidentals Choir Member #5
- Marcia Pelletiere
- The Accidentals Choir Member #6
- Rosamaria Vallese
- The Accidentals Choir Member #7
- Jim Vincent
- The Accidentals Choir Member #8
- Sammy Fine
- Kid
- Paulina Gerzon
- Kid / Denis Leary's daughter
- Lucas Maass
- Kid
- Gracie Markland
- Kid / William Shatner's niece
- Erica Morris
- Kid
- Brett Murphy
- Kid / Denis' Nephew
- Zak Stevens
- Kid
- Ryan Cross
- Actor
- Dan Truman
- Orderly
- Phillip Bloch
- Self
- Karen Chapman
- Nun with a cold
- Jim Creeggan
- Self
- Kevin Hearn
- Self
- Steven Page
- Self
- Raul A. Reyes
- (as Raul Reyes)
- Ed Robertson
- Self
- Tyler Stewart
- Self
