- Yutaka Aoyama
- Professor Mochizuki
- Miho Arakawa
- Meiko Mochizuki
- John Eric Bentley
- Additional Voices
- Johnny Yong Bosch
- T.K. Takaishi
- Robbie Daymond
- Joe Kido
- Dorothy Elias-Fahn
- Yuuko Kamiya
- Jun'ya Enoki
- Takeru Takaishi
- Doug Erholtz
- Daigo Nishijima / Koromon (voice)
- Tom Fahn
- Agumon
- Anna Garduno
- Palmon
- Natsuki Hanae
- Taichi Yagami
- Kyle Hebert
- Greymon / MetalGreymon / WarGreymon (voice)
- Kate Higgins
- Gatomon / Angewomon / Nyaromon / Meicoomon / Meicrackmon Vicious Mode (voice)
- Hiroaki Hirata
- Dark Gennai
- Yoshimasa Hosoya
- Yamato Ishida
- Mao Ichimichi
- Hikari Yagami / Homeostasis (voice)
- Junya Ikeda
- Joe Kido
- Yûko Kaida
- Maki Himekawa
- R. Martin Klein
- Gomamon / Ikkakumon (voice) (as Bob Klein)
- Cherami Leigh
- Biyomon / Yokomon / Maki Himekawa (voice)
- Mona Marshall
- Izzy Izumi
- Miwa Matsumoto
- Tokomon / Patamon / Angemon (voice)
- Vic Mignogna
- Matt Ishida
- Suzuko Mimori
- Sora Takenouchi
- Yukiko Morishita
- Meicoomon / Meicrackmon Vicious Mode (voice)
- Daisuke Namikawa
- Daigo Nishijima
- Jeff Nimoy
- Tentomon / Kabuterimon / MegaKabuterimon / HerculesKabuterimon / Dark Gennai (voice)
- Colleen O'Shaughnessey
- Sora Takenouchi / Mrs. Mochizuki (voice)
- Chika Sakamoto
- Koromon / Agumon / Greymon / MetalGreymon (voice)
- Takahiro Sakurai
- Tentomon / Kabuterimon / AtlurKabuterimon / HerakleKabuterimon (voice)
- Philece Sampler
- Mimi Tachikawa
- Tara Sands
- Kari Kamiya / Homeostasis / News Reporter (voice)
- Joshua Seth
- Tai Kamiya / Motimon (voice)
- Atori Shigematsu
- Yokomon / Piyomon / Birdramon / Yuuko Yagami (voice) (as Katori Shigematsu)
- Melodee Spevack
- Birdramon
- Laura Summer
- Patamon
- Shin'ya Takahashi
- (voice)
- Junko Takeuchi
- Gomamon / Ikkakumon (voice)
- Mutsumi Tamura
- Koushiro Izumi
- Kirk Thornton
- Gabumon / Garurumon (voice)
- Yuka Tokumitsu
- Nyaromon / Tailmon / Angewomon (voice)
- Cristina Valenzuela
- Meiko Mochizuki
- Kinoko Yamada
- Palmon / Togemon (voice)
- Mayumi Yamaguchi
- Gabumon / Garurumon (voice)
- Hitomi Yoshida
- Mimi Tachikawa / Mrs. Mochizuki (voice)
- Mari Devon
- Togemon
- Aaron LaPlante
- Professor Mochizuki
- Jamieson Price
- Angemon
- Paul St. Peter
- Alphamon / IAA Agent (voice) (uncredited)
