- John Lithgow
- Don Quixote de La Mancha / Alonso Quixano
- Bob Hoskins
- Sancho Panza
- Isabella Rossellini
- The Duchess
- Vanessa Williams
- Dulcinea / Aldonza
- Lambert Wilson
- Duke
- Amelia Warner
- Antonia
- Tony Haygarth
- Barber
- Peter Eyre
- Priest
- Lilo Baur
- Teresa Panza (Sancho's wife)
- James Purefoy
- Sansón Carrasco
- Trevor Peacock
- Innkeeper
- Linda Bassett
- Housekeeper
- Barry Stanton
- Chaplain - at the Duke's Feast
- Alun Raglan
- Rodriguez
- Michael Feast
- Doctor
- Graham Crowden
- Montesino
- Amparo Valle
- Mother Panza (Older)
- Alicia Borrachero
- Mother Panza (Younger)
- Ruth Sheen
- 1st Wench / Young Lady
- Rosemary Smith
- 2nd Wench / Young Lady
- Sean Gilder
- Captain
- Amador Pita Gonzales
- Prisoner 1
- Ben Thomas
- Prisoner 2
- John East
- Prisoner 3
- Larry Sheridan
- Prisoner 4
- Francis Magee
- Ginesillo de Parapilla
- Teté Delgado
- Hostess 2nd Inn
- Eileen Bell
- 1st Country Girl
- Ruth Silvestre
- 2nd Country Girl
- Manolo Caro
- Shepherd
- Jessica Oyelowo
- 1st Handmaiden
- Natasha Estelle Williams
- 2nd Handmaiden
- Hannah Mosle-Hughes
- Sanchina
- Mike Kemp
- Mayor
- Rory Edwards
- Duke's Man
- Jorge Casalduero
- 1st Officer
- Leandro Gimenez
- 2nd Officer
- Christopher Neal
- Boy Alonso
- Stephen Giffin
- Herald
- Paco Nones
- Duke's Man 2
- Lucina Gil
- Lady in White
- Michael Culkin
- 1st Monk
- Timothy Bateson
- 2nd Monk
- Balbino Lacosta
- Dentist
- Victoria Navarrete Mandly
- Damsel
- Antonio Gil
- Magician
- Lloyd Williams
- Giant
- Guy E. Williams
- Giant
- Big Greg Essex
- Giant
- Phil Downes
- Giant
- Nicole Moerland
- Princess Pantabalon
- Rosanna Walls
- Waitress
- Amara Carmona
- (uncredited)
- Daniel Fearn
- Young Sancho
