- Matt Groening
- original character designer (124 episodes, 1999-2013)
- Rachel Stratton
- color key artist / color key (86 episodes, 1999-2011)
- Tim Brock
- color key artist / color key (85 episodes, 1999-2012)
- Edgar Duncan
- background and prop designer / background designer / prop designer (85 episodes, 1999-2011)
- Sang Am Lee
- animation checker / overseas animation checker (76 episodes, 1999-2012)
- Bari Kumar
- color supervisor / color key artist (75 episodes, 1999-2012)
- James H. Goldin
- animation accountant (72 episodes, 1999-2003)
- Zeke Johnson
- background and prop designer / background designer / prop designer (72 episodes, 1999-2003)
- Sandra Lee
- digital background painter / color key artist / color key (72 episodes, 1999-2003)
- Lisa Marriott
- digital background painter / color key artist (72 episodes, 1999-2003)
- Debbie Peterson
- background and prop designer / background designer / prop designer (72 episodes, 1999-2003)
- Mike Smith
- director: main title (72 episodes, 1999-2003)
- Samantha Harrison
- color key artist / color supervisor (71 episodes, 1999-2024)
- Jeffrey A. Mertz
- background and prop designer / background designer / prop designer (68 episodes, 1999-2012)
- Peter Maivia
- clean-up artist / background layout artist (68 episodes, 1999-2003)
- Carlos E. Mendez
- clean-up artist (68 episodes, 1999-2003)
- D.J. Kang
- background and prop designer / background layout artist / background designer / prop designer (67 episodes, 1999-2003)
- Doug Gallery
- animation timer (64 episodes, 1999-2003)
- James Peters
- digital background painter (59 episodes, 1999-2003)
- Francisco Rosales
- clean-up artist (55 episodes, 1999-2003)
- Kent Holaday
- lip sync (55 episodes, 1999-2002)
- Steve Socki
- animation timer (52 episodes, 2003-2013)
- David Lee
- character layout artist (47 episodes, 1999-2003)
- Shannon O'Connor
- character designer / character layout artist (44 episodes, 2000-2024)
- Kevin M. Newman
- character designer / character design (38 episodes, 1999-2003)
- Jim Feeley
- character designer (38 episodes, 2001-2003)
- Tom Pope
- character layout artist (33 episodes, 2000-2003)
- Daniel Bond
- design clean-up / character layout artist / background and prop design / background and prop designer / Background & Prop designer / background & prop designer / clean-up artist (33 episodes, 2001-2024)
- Alex Lee
- background layout artist / background and prop designer (29 episodes, 1999-2011)
- Neil Viker
- animation checker (29 episodes, 1999-2000)
- José Zelaya
- character designer (28 episodes, 2001-2003)
- Timothy Hwang
- background and prop designer / background layout artist / background layout (27 episodes, 2000-2011)
- Holly Williams
- color stylist / color key stylist (13 episodes, 2012-2013)
- Derek Lee Thompson
- animation timer / character layout artist (24 episodes, 2001-2012)
- Nam Suk Cho
- background layout artist / background and prop designer / background layout (22 episodes, 1999-2013)
- Tim Long
- animation timer (22 episodes, 1999-2003)
- Dexter Reed
- character layout artist (22 episodes, 1999-2000)
- Ryan Donoghue
- background layout artist / character layout artist (21 episodes, 1999-2003)
- Larry Miravalles
- background layout artist / background layout (21 episodes, 1999-2003)
- Sean Sexton
- character layout artist (20 episodes, 1999-2003)
- Ron Zorman
- animation timer (20 episodes, 1999-2002)
- Brad Forbush
- character layout artist (19 episodes, 1999-2003)
- David Salvador
- character layout artist (19 episodes, 1999-2003)
- Brian Smith
- color key artist / color key (19 episodes, 1999-2000)
- Eric Dunn
- background layout artist / background layout (18 episodes, 1999-2003)
- Pete 'Kid Flash' Gomez
- character layout artist / character designer (18 episodes, 1999-2003)
- Dwayne Carey-Hill
- character designer / character layout artist (18 episodes, 1999-2001)
- Eric S. Keyes
- character designer / character design (18 episodes, 1999-2001)
- Rahul Bhushan
- digital background painter (18 episodes, 2002-2003)
- Charlie Upton
- animation compositor (18 episodes, 2002-2003)
- Karapet Keroglyan
- character designer (18 episodes, 2010-2013)
- Carol Delmindo Datuin
- background layout artist / background layout (17 episodes, 1999-2003)
- Heejin Kim
- background layout artist (17 episodes, 1999-2003)
- Bryan Francis
- character layout artist (17 episodes, 2000-2009)
- Brian Phillipson
- lip sync (17 episodes, 2002-2003)
- Claudia V. Keene
- character designer / reference animation / background and prop design / Background & Prop designer / background and prop designer / design clean-up / reference animator (17 episodes, 2010-2024)
- Acacia Caputo
- lip assignment / animation timer (17 episodes, 2010-2012)
- Chad E. Cooper
- background and prop designer (17 episodes, 2010-2012)
- Alen Esmaelian
- lead background and prop design / background and prop designer / lead background and prop designer / Lead Background & Prop designer / Lead Background & Prop Designer (17 episodes, 2012-2024)
- Fred Kim
- background layout artist / background layout (16 episodes, 1999-2003)
- Celeste Mari Williams
- animation timer (16 episodes, 2001-2003)
- Erben Detrablan
- background layout artist (16 episodes, 2008-2009)
- Drew T. Pierce
- character layout artist (16 episodes, 2008-2009)
- John Seymore
- background & prop designer (16 episodes, 2008-2009)
- Noah Miller
- character layout artist (15 episodes, 1999-2002)
- Kelly Anne Rodak
- 3D Artist / 3D artist (15 episodes, 2023-2024)
- Jeanette Moreno King
- character layout artist (14 episodes, 1999-2003)
- Edemer Santos
- background layout artist / character layout artist (14 episodes, 1999-2003)
- Bart Saric
- digital background painter / color key artist (14 episodes, 1999)
- Galina Budkin
- design clean-up (14 episodes, 2010-2011)
- Patrick Morgan
- digital background painter (14 episodes, 2010-2011)
- Anne Legge
- color key artist (13 episodes, 1999)
- David Swift
- character designer (13 episodes, 1999)
- T.J. Kim
- background layout artist (13 episodes, 2000-2003)
- Jennifer Moeller
- character layout artist (13 episodes, 2000-2003)
- Stephanie Arnett
- character layout artist (12 episodes, 1999-2003)
- Tom King
- character layout artist (12 episodes, 1999-2003)
- Anna Chambers
- character designer (12 episodes, 1999-2000)
- Kenny McGill
- background layout artist (12 episodes, 2008-2009)
- Roger Viloria
- key animator / character layout artist (12 episodes, 2008-2009)
- Patrick Gleeson
- animation timer / timing / timer (12 episodes, 2011-2024)
- Michael Camacho
- design clean-up / background and prop design (12 episodes, 2023-2024)
- Alice Darrow
- character designer (12 episodes, 2023-2024)
- Janice Tolentino
- character layout artist (11 episodes, 1999-2003)
- David Bastian
- timing supervisor / animation timer (11 episodes, 2002-2024)
- Junyi Zhang April
- background and prop design / background and prop designer / Background & Prop designer / Background & Prop desinger (11 episodes, 2023-2024)
- Winona Noronha
- color key / color key artist (10 episodes, 2023-2024)
- Andrew Phillipson
- background and prop design / background and prop designer / Background & Prop designer / background & prop designer (11 episodes, 2023-2024)
- John Aoshima
- character layout artist (10 episodes, 1999-2002)
- Juliana Korsborn
- character layout artist (9 episodes, 1999-2002)
- Erin Bozon
- character layout artist (10 episodes, 1999-2000)
- Ernie Keen
- character layout artist (10 episodes, 2001-2003)
- Arthur Valencia
- character layout artist (10 episodes, 2001-2003)
- Mark Bykov
- animation timer (10 episodes, 2001-2002)
- Jill Jacobs
- animation timer (10 episodes, 2010-2012)
- Maurice Morgan
- background and prop designer (10 episodes, 2010-2012)
- Alexandra Kasenda
- background and prop design / background and prop designer / Background & Prop designer (10 episodes, 2023-2024)
- Anthony Agrusa
- character layout artist (9 episodes, 1999-2003)
- Pam Cooke
- character layout artist (9 episodes, 1999-2001)
- Yacine Elghorri
- character designer (9 episodes, 1999)
- John Rosen
- clean-up artist (9 episodes, 1999)
- Richard Manginsay
- character layout artist (9 episodes, 2001-2003)
- Joe McGrory
- Background & Prop designer / background and prop design / background and prop designer (9 episodes, 2023-2024)
- Hayley Neighbors
- background and prop design / Background & Prop designer / background and prop designer (9 episodes, 2023-2024)
- Kasey Schiavone
- color key artist / background painter / color key artist: Kasey Schiavone (9 episodes, 2023-2024)
- Ray Claffey
- animation timer / character layout artist (8 episodes, 1999-2003)
- Heidi Guedel
- character layout artist (8 episodes, 1999-2000)
- Jon L. Hooper
- character layout artist (8 episodes, 2000-2003)
- Anna Saunders
- character layout artist (8 episodes, 2000-2003)
- Greg Ramsey
- character layout artist (8 episodes, 2000-2002)
- Orlando Gumatay
- character layout artist (8 episodes, 2001-2003)
- Peter Hixson
- animation timer (8 episodes, 2002-2003)
- Scott Moot
- background and prop designer (8 episodes, 2010-2011)
- Devon Decker
- background & prop designer / background and prop designer / Background & Prop designer (8 episodes, 2023-2024)
- Sydney Mills
- timer / timing (8 episodes, 2023-2024)
- Evan River Pitkin
- fx animation / FX animation (8 episodes, 2023-2024)
- Weston Powers
- fx animation / FX animation / fx animator (8 episodes, 2023-2024)
- Edgar Larrazábal
- timer / animation timer / timing (7 episodes, 1999-2024)
- Carlton Batten
- timing / timing director (7 episodes, 1999-2023)
- Ruth Daly
- character layout artist (7 episodes, 1999-2002)
- Susan Forbush
- character layout artist (7 episodes, 1999-2001)
- Chris Sauve
- animation timer (7 episodes, 1999)
- Eric Whited
- lead 3D artist / 3-D animator: main title (7 episodes, 2000-2023)
- Eddie Rosas
- character layout artist (7 episodes, 2000-2003)
- Perfecto Badillo
- character layout artist (7 episodes, 2000-2002)
- Crystal Chesney
- character layout artist (7 episodes, 2001-2003)
- Jansen Yee
- character layout artist (7 episodes, 2001-2003)
- Yvette Kaplan
- animation timer (7 episodes, 2010-2011)
- Yvonne Annette Huckell
- color key artist / design clean-up (7 episodes, 2011-2013)
- Mary Hoffman
- character designer (7 episodes, 2023-2024)
- Kevin Chiya Kuan
- background & prop designer / Background & Prop designer / background and prop design (7 episodes, 2023-2024)
- Emma McLaren-Cobb
- color key artist / color key stylist (7 episodes, 2023-2024)
- Jae H. Kim
- character layout artist (6 episodes, 1999-2003)
- John Krause
- background and prop designer (6 episodes, 1999)
- Aimee Steinberger
- character layout artist (6 episodes, 2001-2003)
- Philip Garcia
- character layout artist (6 episodes, 2001-2002)
- Poe K. Tan
- background layout artist (6 episodes, 2001-2002)
- Carlos Gutierrez
- background and prop designer / Background & Prop designer / background and prop design (6 episodes, 2023-2024)
- Reid Monninger
- background and prop designer / Background & Prop designer / background and prop design (6 episodes, 2023-2024)
- John MacFarlane
- FX animation (6 episodes, 2023)
- Frank Marino
- timing (6 episodes, 2023)
- Jose Manuel Salas
- 3D artist (6 episodes, 2023)
- Shea Wheeler
- timing (6 episodes, 2023)
- Wan Lee
- digital bg painter / bg painter (6 episodes, 2024)
- Kat Lyons
- digital bg painter / bg painter (6 episodes, 2024)
- Faye Thomas
- timer / timing (6 episodes, 2024)
- Kevin Thresher
- timer / timing (6 episodes, 2024)
- Linda Dorn
- character layout artist (5 episodes, 1999-2000)
- Brian Tribble
- character layout artist (5 episodes, 1999-2000)
- Julius Aguimatang
- character layout artist (5 episodes, 1999)
- Vladimir Zaval
- background layout artist (5 episodes, 1999)
- Brian Hatfield
- character layout artist (5 episodes, 2000)
- Paul Myers
- character layout artist (5 episodes, 2001-2002)
- T.C. Starnes Jr.
- background layout artist (5 episodes, 2002-2003)
- Hunilla Fodor
- timer: Huni Fodor / timer / timing: Huni Fodor (5 episodes, 2024)
- Jess Espanola
- character layout artist (4 episodes, 1999-2003)
- William Bon
- background layout artist (4 episodes, 1999-2000)
- Scott Buckley
- background layout artist (4 episodes, 1999-2000)
- Kevin O'Brien
- storyboard artist (4 episodes, 1999-2000)
- Donald Shaw
- character layout artist (4 episodes, 1999-2000)
- Arthur Ebuen
- character layout artist (4 episodes, 1999)
- Ashanti Miller
- character layout artist (4 episodes, 1999)
- Tom Mazzocco
- animation timer (4 episodes, 2000)
- Angela Mueller
- character layout artist (4 episodes, 2001-2002)
- Soung Wook Koh
- character layout artist (4 episodes, 2002-2003)
- Sarge Morton
- character layout artist (4 episodes, 2002-2003)
- Chris Sonnenburg
- character layout artist (4 episodes, 2002-2003)
- Bradley J. Gake
- background layout artist (4 episodes, 2008)
- Carolyn Roach
- production assistant (4 episodes, 2010)
- Chad Woods
- color key artist (4 episodes, 2010)
- Alex Chao
- digital background painter (4 episodes, 2013)
- Leasa Epps-Eisele
- background and prop design (4 episodes, 2023)
- Brice Mallier
- FX animation (4 episodes, 2023)
- Ashley Lenz
- character layout artist (3 episodes, 1999-2000)
- James Purdum
- animation timer (3 episodes, 1999-2000)
- Aaron Clark
- background layout artist (3 episodes, 1999)
- Michael Dowell
- character layout artist (3 episodes, 1999)
- Jamie Frye
- digital background painter (3 episodes, 1999)
- Benjamin Dai
- character layout artist (3 episodes, 2001-2002)
- Stevan Wahl
- character layout artist (3 episodes, 2002-2003)
- Greg Checketts
- character layout artist (3 episodes, 2003)
- Jason Plapp
- digital background painter (3 episodes, 2012)
- Sean Rhyan
- digital background painter (3 episodes, 2012)
- Sam Im
- timing (3 episodes, 2023)
- Gannon Rialti
- background painter (3 episodes, 2023)
- Seonggyu Kim
- animation director (3 episodes, 2024)
- Sunghoon Kim
- animation director (3 episodes, 2024)
- Mark Ramirez
- character layout artist (2 episodes, 1999-2001)
- Marcos Asprec
- character layout artist (2 episodes, 1999)
- Young Ho Cho
- layout team: Rough Draft Korea (2 episodes, 1999)
- Karl Fischer
- animation timer (2 episodes, 1999)
- Dae Hoon Kang
- layout team: Rough Draft Korea (2 episodes, 1999)
- Majella Milne
- animation timer (2 episodes, 1999)
- Chang Shin Park
- layout team: Rough Draft Korea (2 episodes, 1999)
- Aaron Rozenfeld
- character layout artist (2 episodes, 1999)
- Woong Kee Song
- layout team: Rough Draft Korea (2 episodes, 1999)
- Seung Ryong Um
- layout team: Rough Draft Korea (2 episodes, 1999)
- Chris Chua
- character layout artist (2 episodes, 2001)
- Roger Gonzales
- character layout artist (2 episodes, 2001)
- Sunil Hall
- character layout artist (2 episodes, 2002)
- Susie Dietter
- character layout artist (2 episodes, 2003)
- Dave Lyman
- animation timer / timer (2 episodes, 2012-2013)
- David J. Chung
- background and prop designer (2 episodes, 2013)
- Lizzie Nichols
- background and prop designer (2 episodes, 2013)
- Edward Artinian
- FX animation (2 episodes, 2023)
- Andrea Sutjipta
- color key stylist (2 episodes, 2023)
- Cyndi Tang
- timing (2 episodes, 2023)
- Haksoo Mok
- animation director (2 episodes, 2024)
- Phil Cummings
- animation timer (1 episode, 1999)
- Ron Hughart
- animation timer (1 episode, 1999)
- Jerry Richardson
- character designer (1 episode, 1999)
- Deke Wightman
- character layout artist (1 episode, 1999)
- Susan M. Zytka
- character layout artist (1 episode, 1999)
- Peter Browngardt
- character layout artist (1 episode, 2000)
- Conan Low
- 3-D animator: main title (1 episode, 2000)
- John Mathot
- character designer (1 episode, 2000)
- Yumun Jeong
- character layout artist (1 episode, 2001)
- Colin Heck
- character layout artist (1 episode, 2002)
- Istvan Majoros
- character layout artist (1 episode, 2003)
- Robert Ingram
- timing (1 episode, 2023)
- Wyatt Lavasseur
- 3D artist (1 episode, 2023)
- Moon Seok Baek
- animation director (1 episode, 2024)
- Shin Hwan Chang
- animation director (1 episode, 2024)
- Shelby Hacker
- color key artist (1 episode, 2024)
- Young Jung Kim
- animation director (1 episode, 2024)
- Sae Chang Kwak
- animation director (1 episode, 2024)
- Hae Sung Park
- animation director (1 episode, 2024)
- Dale Hendrickson
- original character designer (uncredited) (72 episodes, 1999-2003)
- Bill Morrison
- original character designer (uncredited) (72 episodes, 1999-2003)
- Mili Smythe
- original character designer (uncredited) (72 episodes, 1999-2003)
- Joe Suggs
- character layout artist (uncredited) (1 episode, 1999)
