- Bob Denver
- Â Gilligan / ... 99 episodes, 1964-1992
- Alan Hale Jr.
- Â Jonas 'The Skipper' Grumby / ... 99 episodes, 1964-1992
- Jim Backus
- Â Thurston Howell III / ... 99 episodes, 1964-1992
- Natalie Schafer
- Â Mrs. Lovey Howell / ... 99 episodes, 1964-1992
- Tina Louise
- Â Ginger Grant / ... 98 episodes, 1964-1967
- Russell Johnson
- Â Professor Roy Hinkley / ... 98 episodes, 1964-1967
- Dawn Wells
- Â Mary Ann Summers / ... 98 episodes, 1964-1967
- Charles Maxwell
- Â Radio Announcer 1 episode, 1964-1965
- Janos Prohaska
- Â Gorilla / ... 1 episode, 1965-1967
- Vito Scotti
- Â Dr. Boris Balinkoff / ... 4 episodes, 1965-1966
- Eddie Little Sky
- Â Native / ... 3 episodes, 1965-1966
- Mel Blanc
- Â Parrot / ... 3 episodes, 1964-1965
- Russ Grieve
- Â Head Hunter / ... 1 episode, 1965
- Hans Conried
- Â Wrongway Feldman 2 episodes, 1964-1965
- Denny Miller
- Â Duke Williams / ... 2 episodes, 1965-1967
- Chick Hearn
- Â Commentator / ... 1 episode, 1967
- George N. Neise
- Â Interviewer / ... 1 episode, 1966-1967
- James Spencer
- Â Copilot / ... 1 episode, 1966-1967
- Kit Smythe
- Â Ginger 1 episode, 1992
- John Gabriel
- Â The Professor 1 episode, 1992
- Nancy McCarthy
- Â Bunny 1 episode, 1992
- Kurt Russell
- Â Jungle Boy 1 episode, 1965
- Zsa Zsa Gabor
- Â Erika Tiffany-Smith 1 episode, 1965
- Larry Storch
- Â Jackson Farrell 1 episode, 1965
- Nehemiah Persoff
- Â Pancho Hernando Gonzalez Enriques Rodriguez 1 episode, 1965
- Harold J. Stone
- Â Alexandre Gregor Dubov 1 episode, 1965
- Vincent Beck
- Â Igor 1 episode, 1965
- Booth Colman
- Â Professor John Corwell 1 episode, 1965
- Henny Backus
- Â Native Mother 1 episode, 1965
- Les Brown Jr.
- Â Bingo 1 episode, 1965
- Richard Kiel
- Â Russian Agent / ... 1 episode, 1966
- Don Rickles
- Â Norbett Wiley 1 episode, 1966
- John McGiver
- Â Lord Beasley Waterford 1 episode, 1966
- Phil Silvers
- Â Harold Hecuba 1 episode, 1966
- Sterling Holloway
- Â Burt 1 episode, 1967
- Strother Martin
- Â George Barkley 1 episode, 1967
- Rory Calhoun
- Â Jonathan Kincaid 1 episode, 1967
- Stanley Adams
- Â King Kaliwani 1 episode, 1967
- Frank Maxwell
- Â General 1 episode, 1967
- Midori
- Â Kalani 1 episode, 1967
- Jim Lefebvre
- Â Native 1 episode, 1967
- Rudy LaRusso
- Â Michaels 1 episode, 1967
- William Curtis
- Â Royal Messenger 1 episode, 1967
- Michael Witney
- Â Johnny 1 episode, 1965
- Arthur Peterson
- Â Professor George Bancroft 1 episode, 1965
- The Wellingtons
- Â The Mosquitoes 1 episode, 1965
- Danny Klega
- Â Ivan 1 episode, 1965
- Mike Mazurki
- Â Dog / ... 1 episode, 1966
- Allen Jaffe
- Â Native 1 episode, 1966
- Michael Forest
- Â Ugundi 1 episode, 1967
- Edward Faulkner
- Â Colonel 1 episode, 1967
- Harold Sakata
- Â Ramoo 1 episode, 1967
- Bartlett Robinson
- Â Hartley 1 episode, 1967
- Al Ferrara
- Â Native 1 episode, 1967
- Larry Thor
- Â Newscaster 1 episode, 1965
- Mary Foran
- Â Native Daughter 1 episode, 1965
- Roman Gabriel
- Â Native 1 episode, 1966
- Scott Graham
- Â Sol Tobias 1 episode, 1967
- Walt Hazzard
- Â Lieutenant 1 episode, 1967
- Kirk Duncan
- Â Parsons 1 episode, 1967
- Pete Sotos
- Â Native 1 episode, 1967
- Ed Fury
- Â Navy Lieutenant 1 episode, 1965
- Kirby Johnson
- Â Irving 1 episode, 1965
- Ed Wade
- Â Bongo 1 episode, 1965
- George Patterson
- Â Bango 1 episode, 1965
- Herman
- Â Male Turtle 1 episode, 1965
- Hilda
- Â Female Turtle 1 episode, 1965
- Rex
- Â Skipper's Turtle 1 episode, 1965
- Al Schottelkotte
- Â Al Schottelkotte 1 episode, 1966
- June Foray
- Â Alice McNeil (uncredited) 1 episode, 1964
- Judy the Chimpanzee
- Â Chimp Gilligan / ... (uncredited) 1 episode, 1964
- Herb Vigran
- Â Lucky (uncredited) 1 episode, 1965
- Harry Lauter
- Â Maj. Adams (uncredited) 1 episode, 1965
- Jack Sheldon
- Â Lucky (uncredited) 1 episode, 1965
- Russell Thorson
- Â Gen. Bryan (uncredited) 1 episode, 1965
- Carol Connors
- Â Mary Ann Summers (uncredited) 1 episode, 1965
- Frank Corsentino
- Â Native (uncredited) 1 episode, 1965
- K.L. Smith
- Â Gates - Farrell's Accomplice (uncredited) 1 episode, 1965
- Louis Quinn
- Â Hank (uncredited) 1 episode, 1965
- Bert Madrid
- Â Jose (uncredited) 1 episode, 1965
- Paul Daniel
- Â Native (uncredited) 1 episode, 1965
- Ann Robinson
- Â St. Louis' Bijou Theatre operator (uncredited) 1 episode, 1966
- Sandra Gould
- Â Telephone Operator (uncredited) 1 episode, 1966
- Henry Corden
- Â Commandant (uncredited) 1 episode, 1966
- Zamba
- Â Leo the Lion (uncredited) 1 episode, 1966
- Glenn Langan
- Â Pilot (uncredited) 1 episode, 1966
- Patrick Denver
- Â Little Gilligan (uncredited) 1 episode, 1966
- Robert D'Arcy
- Â Robot (uncredited) 1 episode, 1966
- John Facenda
- Â Self (uncredited) 1 episode, 1966
- Vernon Scott
- Â Radio Announcer (uncredited) 1 episode, 1966
- Mickey Morton
- Â Native #1 (uncredited) 1 episode, 1967
- Harry Swoger
- Â Prison Guard (uncredited) 1 episode, 1967
- Robert Swimmer
- Â Native #2 (uncredited) 1 episode, 1967
- Walter
- Â Pigeon (uncredited) 1 episode, 1967