- Raymond Burr
- Steve Martin
- Takashi Shimura
- Dr. Yamane
- Momoko Kôchi
- Emiko
- Akira Takarada
- Ogata
- Akihiko Hirata
- Dr. Serizawa
- Sachio Sakai
- Hagiwara
- Fuyuki Murakami
- Dr. Tabata
- Ren Yamamoto
- Seiji
- Toyoaki Suzuki
- Shinkichi
- Tadashi Okabe
- Dr. Tabata's Assistant
- Toranosuke Ogawa
- President of Company
- Frank Iwanaga
- Tomo Iwanaga - Security Officer
- Mikel Conrad
- George Lawrence
- Paul Frees
- Unidentified Character
- Fuji
- Police Officer at Airport
- Hiroshi Hayashi
- (uncredited)
- James Hong
- Ogata / Serizawa (voice) (uncredited)
- Ren Imaizumi
- Radio Operator
- Dale Ishimoto
- Dale Ishimoto
- Shigeo Katô
- JSDF with Spotlight - Leader of the Crowd Escaping
- Akio Kusama
- Otoshima Islander
- Kokuten Kôdô
- Old Man on Hill on Oto Island
- Tsuruko Mano
- The Boy's Mother
- Lee Miller
- Man in Line at Airport
- Teruko Mita
- Activist
- Haruo Nakajima
- Godzilla
- Takeo Oikawa
- Chief of Emergency Headquarters
- Kenji Sahara
- Man on Boat
- Keiji Sakakida
- Mayor Inada
- Junnosuke Suda
- Tokaido Line Driver
- Kin Sugai
- (uncredited)
- Ryosaku Takasugi
- Godzilla
- Katsumi Tezuka
- Godzilla
- Sammee Tong
- Dr. Yamane
- Kamayuki Tsubono
- Japan Coast Guard Officer / Shikine Newspaper Reporter (uncredited)
