- Joanna Newsom
- Sortilège
- Katherine Waterston
- Shasta Fay Hepworth
- Joaquin Phoenix
- Larry "Doc" Sportello
- Jordan Christian Hearn
- Denis
- Taylor Bonin
- Ensenada Slim
- Jeannie Berlin
- Aunt Reet
- Josh Brolin
- Lt. Det. Christian F. "Bigfoot" Bjornsen
- Eric Roberts
- Michael Z. Wolfmann
- Serena Scott Thomas
- Sloane Wolfmann
- Maya Rudolph
- Petunia Leeway
- Martin Dew
- Dr. Buddy Tubeside
- Michael Kenneth Williams
- Tariq Khalil
- Hong Chau
- Jade
- Shannon Collis
- Bambi
- Christopher Allen Nelson
- Glenn Charlock
- Benicio Del Toro
- Sauncho Smilax, Esq
- Catherine Haena Kim
- News Reporter
- Jena Malone
- Hope Harlingen
- Owen Wilson
- Coy Harlingen
- Vivienne Khaledi
- Amethyst Harlingen
- Yvette Yates Redick
- Luz
- Andrew Simpson
- Riggs Warbling
- Joe Dioletto
- Cop with Bigfoot
- Reese Witherspoon
- Deputy D.A. Penny Kimball
- Sam Jaeger
- Agent Flatweed
- Timothy Simons
- Agent Borderline
- Jack Kelly
- Burke Stodger
- Jillian Bell
- Chlorinda
- Christian Williams
- Smedley
- The Growlers
- The Boards
- Belladonna
- Clancy Charlock
- Alina Gatti
- Howdy Doper's Phone Voice
- Elaine Tan
- Xandra
- Martin Short
- Dr. Rudy Blatnoyd, D.D.S.
- Sasha Pieterse
- Japonica Fenway
- Wilson Bethel
- LAPD Officer #1
- Anders Holm
- LAPD Officer #2
- Emmet Unverzagt
- Bigfoot's Kid
- Jefferson Mays
- Dr. Threeply
- Erica Sullivan
- Dr. Lily Hammer
- Eva Fisher
- Dr. Threeply's Assistant #1
- Jackie Michele Johnson
- Dr. Threeply's Assistant #2
- Katie Schwartz
- Kimberly
- Charley Morgan
- Dr. Igor
- Keith Jardine
- Puck Beaverton
- Delaina Hlavin
- Mrs. Chastity Bjornsen
- Michael Cotter
- Rhus Frothingham
- Peter McRobbie
- Adrian Prussia
- Shannon C. Sullivan
- Adrian Prussia's Secretary
- Martin Donovan
- Crocker Fenway
- Samantha Lemole
- Golden Fang Mother
- Madison Leisle
- Golden Fang Daughter
- Liam Van Joosten
- Golden Fang Son
- Matt Doyle
- Golden Fang Father
- David Prak
- Buddhist Monk
- Amy Ferguson
- Bodhi
- Emma Dumont
- Zinnia
- Scott Aschenbrenner
- Jesus Guard
- Jacqueline Ash
- Chryskolodon Nurse
- Ashleigh Biller
- Patient
- Christina Bobrowsky
- Patient
- Peter Bonilla
- Police Officer
- Gregoer Boru
- Recording Tech
- Marianne Bourg
- Beach Girl
- Toyia Brown
- Harmony
- Stu Brumbaugh
- Groupie
- Will C.
- Commando
- Seth Cash
- Detective
- Elizabeth Colunga
- Patient
- Emma Cooper
- Groupie
- Mars Crain
- Tariq
- Grace Dambier
- Dental Hygienist
- Jordan David
- (uncredited)
- Nicholas de Graffenreid
- Patient
- Adam Dorsey
- Jesus Guard
- Ken Edling
- Judge
- Jenna Emery
- Groupie
- Kelsey Farrar
- Beach Girl
- Al Function
- Biker
- Brandy Futch
- Flight Attendant
- Laura Kranz Galvan
- Chryskylodon Patient
- Lauren Goncher
- Dental Assistant
- Ellen Ho
- Chinese Waitress
- Jessica Huss
- Speed Freak
- Dallas James
- Auto Mechanic
- Christopher Karl Johnson
- Mr. Robinson
- Timothy Lally
- Commando
- Adeana Lane
- Beach Girl
- Kira Legg
- Groupie
- Tracy Ann Lisa
- District Attorney
- Blue LoLan
- Patient
- Dakota Lupo
- Chief Chanter
- Jacob Lyman
- Mormon FBI Agent
- Amanda Maddox
- Flight Attendant
- Emilee Madrak
- Groupie
- Sophia Markov
- Amethyst Harlingen
- Victoria Markov
- Amethyst Harlingen
- Kirstin Masters
- Dental Assistant
- Richard Nixon
- Self
- Shaun Parker
- Commando
- Robert Peoples
- Patient
- Brook Power
- Hippie girl
- Rodney J. Richards
- Adrian Prussia Friend
- Laura Rossi
- Groupie
- Philip Ruiz
- Hippie in Commune
- Osamu Saito
- Japanese waiter Kenichiro
- Joel Shock
- Police officer
- Matthew Skomo
- Detective
- Mark Stepanek
- Record Executive
- Danny Terminello
- Young Jean-Claude Van Damme
- Chantal Thuy
- Groupie
- Diana Elizabeth Torres
- Lourdes
- JC Tremblay
- Chanter
- Robin Tweed
- Attorney
- Michael Twombley
- Biker
- Steven Wiig
- Portola Barkeep
- Daniel Yobaccio
- Patient
