- Sôkô Wada
- Otoha
- Takahiro Sakurai
- Eko
- Johnny Yong Bosch
- Reiji
- Dorothy Elias-Fahn
- Yoshiko Sagisaka
- Sandy Fox
- Amefuriko
- Jay Hernandez
- Nue
- Lex Lang
- Announcer / Shako (voice)
- Wendee Lee
- Mary / Ohkubo Hospital Director (voice)
- Matthew Lillard
- Eko
- Michael McConnohie
- Chief of Police
- Mary Elizabeth McGlynn
- Tsuchigumo
- Steve Staley
- Karas / Otoha (voice)
- Doug Stone
- Detective Minoru Sagisaka
- Kim Strauss
- Security Guard
- Cree Summer
- Yurine
- Kaiji Tang
- Gangster
- Dave Wittenberg
- Detective Minoru Kure
