- Edward G. Robinson
- Caesar Enrico 'Rico' Bandello / 'Little Caesar'
- Douglas Fairbanks Jr.
- Joe Massara
- Glenda Farrell
- Olga Stassoff
- William Collier Jr.
- Tony Passa
- Sidney Blackmer
- Big Boy
- Ralph Ince
- Pete Montana
- Thomas E. Jackson
- Sgt. Flaherty
- Stanley Fields
- Sam Vettori
- Maurice Black
- Little Arnie Lorch
- George E. Stone
- Otero
- Armand Kaliz
- De Voss
- Nicholas Bela
- Ritz Colonna
- Ernie Adams
- Cashier
- Elmer Ballard
- Undetermined Role
- Ferike Boros
- Mrs. Passa
- Kernan Cripps
- Detective
- George Daly
- Machine-Gunner
- Adolph Faylauer
- New Year's Celebrant
- Ben Hendricks Jr.
- Kid Bean
- Al Hill
- Rico's 'Butler'
- Lucille La Verne
- Ma Magdalena
- Gladys Lloyd
- McClure Guest
- Noel Madison
- Killer Peppi
- Tom McGuire
- Detective on Phone
- Louis Natheaux
- Hood
- William H. O'Brien
- Waiter
- Henry Sedley
- Scabby
- Gay Sheridan
- Nightclub Patron
- Larry Steers
- McClure Guest
- Landers Stevens
- Alvin McClure - Crime Commissioner
- Mike Tellegen
- Bodyguard
- Robert Walker
- Lorch Henchman
