- Kevin McKidd
- Â Lucius Vorenus 22 episodes, 2005-2007
- Ray Stevenson
- Â Titus Pullo 22 episodes, 2005-2007
- Polly Walker
- Â Atia of the Julii 22 episodes, 2005-2007
- Kerry Condon
- Â Octavia of the Julii 22 episodes, 2005-2007
- James Purefoy
- Â Mark Antony 22 episodes, 2005-2007
- Ian McNeice
- Â Newsreader 20 episodes, 2005-2007
- Coral Amiga
- Â Vorena the Elder 19 episodes, 2005-2007
- Lindsay Duncan
- Â Servilia of the Junii 18 episodes, 2005-2007
- Lidia Biondi
- Â Merula 18 episodes, 2005-2007
- Tobias Menzies
- Â Marcus Junius Brutus 17 episodes, 2005-2007
- Nicholas Woodeson
- Â Posca 17 episodes, 2005-2007
- David Bamber
- Â Marcus Tullius Cicero 15 episodes, 2005-2007
- Chiara Mastalli
- Â Eirene 15 episodes, 2005-2007
- Manfredi Aliquo
- Â Castor 15 episodes, 2005-2007
- Indira Varma
- Â Niobe 15 episodes, 2005-2007
- Suzanne Bertish
- Â Eleni 14 episodes, 2005-2007
- Max Pirkis
- Â Gaius Octavian 13 episodes, 2005-2007
- Lee Boardman
- Â Timon 13 episodes, 2005-2007
- Esther Hall
- Â Lyde 13 episodes, 2005-2007
- Ciarán Hinds
- Â Gaius Julius Caesar 13 episodes, 2005-2007
- Anna Fausta Primiano
- Â Vorena the Younger 12 episodes, 2005-2007
- Michael Nardone
- Â Mascius 10 episodes, 2005-2007
- Kenneth Cranham
- Â Pompey Magnus 8 episodes, 2005
- Allen Leech
- Â Marcus Vipsanius Agrippa 8 episodes, 2007
- Guy Henry
- Â Cassius 8 episodes, 2005-2007
- Anna Francolini
- Â Clarissa 8 episodes, 2005-2007
- Simon Woods
- Â Gaius Octavian Caesar 7 episodes, 2007
- Zuleikha Robinson
- Â Gaia 7 episodes, 2007
- Karl Johnson
- Â Porcius Cato 7 episodes, 2005
- Alex Wyndham
- Â Gaius Maecenas 7 episodes, 2007
- Paul Jesson
- Â Scipio 7 episodes, 2005
- Camilla Rutherford
- Â Jocasta 7 episodes, 2007
- Daniel Cerqueira
- Â Memmio 7 episodes, 2007
- Alessio Cuna
- Â Lucius 7 episodes, 2007
- Lorcan Cranitch
- Â Erastes Fulmen 6 episodes, 2005-2007
- Nigel Lindsay
- Â Levi 6 episodes, 2007
- Valery Usai
- Â Vorena the Younger 6 episodes, 2007
- Lyndsey Marshal
- Â Cleopatra 5 episodes, 2005-2007
- Haydn Gwynne
- Â Calpurnia 5 episodes, 2005-2007
- Dominic Atherton
- Â Yesh 5 episodes, 2007
- Julienne Liberto
- Â Mary 5 episodes, 2007
- Rick Warden
- Â Quintus Pompey 4 episodes, 2005-2007
- Amy Marston
- Â Deborah 5 episodes, 2007
- Sara Pasqualone
- Â Bec 5 episodes, 2007
- Liliana Mele
- Â Cleopatra's Assistant 4 episodes, 2005-2007
- Enzo Cilenti
- Â Evander Pulchio 4 episodes, 2005
- Alan Williams
- Â Acerbo 4 episodes, 2007
- Kathryn Hunter
- Â Charmian 4 episodes, 2005-2007
- Alessio Di Cesare
- Â Rubio 4 episodes, 2005
- Marco Pollak
- Â Lucius 4 episodes, 2005
- Cosimo Fusco
- Â Hannibal Cotta 4 episodes, 2007
- David Quinzi
- Â Rubio 4 episodes, 2005
- Clive Riche
- Â Tyro 4 episodes, 2007
- Ronan Vibert
- Â Lepidus 4 episodes, 2007
- John Boswall
- Â Curial Magistrate 4 episodes, 2005
- Andrea De Santis
- Â Phidias 4 episodes, 2005
- Rafi Gavron
- Â Duro 3 episodes, 2007
- Maxim Baldry
- Â Caesarion 3 episodes, 2007
- Kevin Dignam
- Â Lictor / ... 3 episodes, 2005-2007
- Alice Henley
- Â Livia Drusilla 3 episodes, 2007
- Matt Patresi
- Â Durio 3 episodes, 2005
- Anna Patrick
- Â Cornelia 3 episodes, 2005
- Roberto Davide
- Â Glabius 3 episodes, 2005
- Rocky Marshall
- Â Omnipor 3 episodes, 2007
- Nico Toffoli
- Â Roman Legionaire 2 episodes, 2005
- Ewan Bailey
- Â Pertinax 2 episodes, 2005
- David Kennedy
- Â Lucius Septimius 2 episodes, 2005
- Frank Baker
- Â Doctor 2 episodes, 2005
- Eliza Darby
- Â Daughter of Pompey 2 episodes, 2005
- Stefan Brown
- Â Lucius 2 episodes, 2007
- Giovanni Calcagno
- Â Vercingetorix 2 episodes, 2005
- Alexander Brooks
- Â Milo 2 episodes, 2005
- Roger Hammond
- Â Chief Augur 2 episodes, 2005
- Graham McTavish
- Â Urbo 2 episodes, 2005
- Michele Pettini
- Â Son of Pompey 2 episodes, 2005
- Sean Madden
- Â Otho 2 episodes, 2005
- Deborah Moore
- Â Alfidia 2 episodes, 2007
- Federico Firmani
- Â Gaul Boss 2 episodes, 2007
- Anne Lambton
- Â Pharmacopolist 2 episodes, 2007
- Giacomo Gonnella
- Â Carbo 2 episodes, 2007
- Bart Ruspoli
- Â Antony's Tribune / ... 2 episodes, 2005
- Antonio Ragusa
- Â Legionary 2 episodes, 2005
- Javier Torrecillas
- Â Barca / ... 2 episodes, 2007
- Paolo Risi
- Â Cato the Dwarf 2 episodes, 2005
- Nuccio Siano
- Â Saul 2 episodes, 2007
- Ted Rusoff
- Â Strabo 2 episodes, 2005
- Rebekah Staton
- Â Althea 2 episodes, 2007
- Carlotta Montanari
- Â Beggar 1 episode, 2005-2007
- Shaka Bunsie
- Â Hutto 1 episode, 2005
- Charlie Anson
- Â Emmissary 1 episode, 2007
- Scott Chisholm
- Â King Ptolemy XIII 1 episode, 2005
- Ene Frost
- Â Nubian Soldier 1 episode, 2005
- Tony Guilfoyle
- Â Pothinus 1 episode, 2005
- Daren Elliott Holmes
- Â Fulvio 1 episode, 2005
- Michael Culkin
- Â Presiding Magistrate 1 episode, 2005
- Richard Dillane
- Â Centurion Vallo 1 episode, 2007
- Jonathan Coy
- Â Actor for Cato 1 episode, 2005
- Norma Atallah
- Â Female Merchant 1 episode, 2005
- Douglas Dean
- Â Lawyer #1 1 episode, 2005
- Matthew Eggleton
- Â Egyptian Courtier 1 episode, 2007
- Lynda Baron
- Â Madame 1 episode, 2005
- David de Keyser
- Â Theodotus 1 episode, 2005
- Peter Eyre
- Â Accusator Nigidius 1 episode, 2005
- Vincenzo Nicoli
- Â Lysandros 1 episode, 2005
- Allan Caister Pearce
- Â Head Priest 1 episode, 2005
- Dominic Coleman
- Â Centurion 1 episode, 2005
- Francesca Berrettini
- Â Cynthia 1 episode, 2005
- Grant Masters
- Â Achillas 1 episode, 2005
- Peter-Hugo Daly
- Â Heckler 1 episode, 2005
- Paul Kynman
- Â Gladiator #2 1 episode, 2005
- Nicholas Hewetson
- Â Terrified Man 1 episode, 2005
- Fabio Carfora
- Â Sextus 1 episode, 2005
- Damiani Lorenza Zoe
- Â Venus 1 episode, 2005
- Sara Kestelman
- Â The Old Witch 1 episode, 2007
- Noa Bodner
- Â Prostitute 1 episode, 2007
- Chris Anderson
- Â Aide de Camp 1 episode, 2007
- Adam Levy
- Â Saul 1 episode, 2005
- Abhin Galeya
- Â Oedipus 1 episode, 2005
- Bruce Mackinnon
- Â Priscus Maevius 1 episode, 2005
- Andrew Greenough
- Â Appius 1 episode, 2005
- Peter Gevisser
- Â Casca 1 episode, 2005
- Francesco Sensi
- Â Legionary 1 episode, 2005
- Lydia Leonard
- Â Julia 1 episode, 2005
- Simon Callow
- Â Publius Servilius 1 episode, 2005
- John Bennett
- Â Elderly Priest 1 episode, 2005
- Simon Gregor
- Â Artist 1 episode, 2005
- Steve Swinscoe
- Â Officer 1 episode, 2005
- Cristina Mantis
- Â Prostitute #1 1 episode, 2005
- Alessandro Inchiappa
- Â Courier 1 episode, 2005
- Axel Schumacher
- Â Sentry 1 episode, 2005
- Tim Barlow
- Â Ancient Blind Oracle 1 episode, 2007
- Giorgio Antonini
- Â Guardsman 1 episode, 2007
- Kammy Darweish
- Â Rhodomates 1 episode, 2007
- Nicolo Brecci
- Â Caesarion 1 episode, 2007
- Russell Byrne
- Â Tribune 1 episode, 2007
- Stefano Consolini
- Â Cantor 1 episode, 2007
- Russell Mabey
- Â Crucified Man 1 episode, 2005
- Franco Troscia
- Â Body Slave 1 episode, 2005
- Maura Orefici
- Â Priest 1 episode, 2005
- Tim Faraday
- Â Chief Legionary 1 episode, 2007
- Jack Ellis
- Â Bibulus 1 episode, 2007
- Mimmo Esposito
- Â Augur 1 episode, 2007
- Nadia Baldi
- Â Mrs. Bubo 1 episode, 2007
- Francesca Fowler
- Â Egeria 1 episode, 2005
- Francesca Romana Coluzzi
- Â Demeter 1 episode, 2005
- Steven Matthew
- Â Prisoner 1 episode, 2005
- Edward de Souza
- Â Rich Merchant 1 episode, 2007
- Adriana De Guilmi
- Â Chaperone 1 episode, 2007
- Stefano Gragnani
- Â Old Man 1 episode, 2007
- Georgie Glen
- Â Poppea 1 episode, 2005
- Stefano Miceli
- Â Lawyer #2 1 episode, 2005
- Vernon Dobtcheff
- Â Rabbi 1 episode, 2007
- Andy Linden
- Â Procurator 1 episode, 2007
- Bruno Bilotta
- Â Appius 1 episode, 2007
- Tyrone Huggins
- Â Bestiary 1 episode, 2007
- Paolo Paoloni
- Â Priest 1 episode, 2007
- Danny Midwinter
- Â Gladiator #1 1 episode, 2005
- Stu Rosen
- Â Numa 1 episode, 2005
- Bob Mercer
- Â Slave Trader 1 episode, 2005
- Francesco Pini
- Â Slave Dealer 1 episode, 2005
- Jay Simpson
- Â Triolus 1 episode, 2007
- Allan Corduner
- Â Clerk 1 episode, 2007
- Hugh Sachs
- Â Clerk 1 episode, 2005
- Gerard Monaco
- Â Lyco 1 episode, 2005
- Richard Katz
- Â Volpe 1 episode, 2005
- Dominic Rickhards
- Â Aquinas 1 episode, 2005
- Eddie Osei
- Â African Barkeep 1 episode, 2005
- Alessandra Stordy
- Â Iolanthe 1 episode, 2005
- Sergio Di Pinto
- Â Stilicho 1 episode, 2005
- Alessandro Cremona
- Â Pontic Dignitary 1 episode, 2007
- Roberto Sgarbi
- Â Horseman 1 episode, 2007
- Paola Lavini
- Â Phyllis 1 episode, 2005
- Alessandro Prete
- Â Tarquin 1 episode, 2005
- Luigi Santamaria
- Â Flamen Priest 1 episode, 2005
- Christopher Sciueref
- Â Soldier #1 1 episode, 2007
- David Toole
- Â Man with no legs 1 episode, 2007
- Ian Gunn
- Â Confidential Agent 1 episode, 2007
- Pip Torrens
- Â Cimber 1 episode, 2005
- Barbara Marten
- Â Diviner 1 episode, 2005
- Massimo Pupella
- Â Whistling Legionary 1 episode, 2005
- Stan Rosen
- Â Numa 1 episode, 2005
- Linal Haft
- Â Bearded Man 1 episode, 2007
- Emilio De Marchi
- Â Vizier 1 episode, 2007
- Andrew Scarborough
- Â Milo 1 episode, 2005
- Maggie McCarthy
- Â Drusilla 1 episode, 2005
- Parvez Qadir
- Â Tanjit 1 episode, 2005
- Carla Cagnetti
- Â Maidservent 1 episode, 2005
- Valerio Isidori
- Â Blinded Man 1 episode, 2007
- Simon Smith
- Â Overseer 1 episode, 2007
- Julian Rivett
- Â Lawyer #3 1 episode, 2005
- Vittorio Amandola
- Â Proculus 1 episode, 2005
- Michele Melega
- Â Head Priest 1 episode, 2007
- Kevin Johnson
- Â Guard 1 episode, 2007
- Alessandro Ruo
- Â Pontifex Maximus 1 episode, 2007
- Jonathan Readwin
- Â Crito 1 episode, 2005
- Oreste Rotundo
- Â Aufidius Dento 1 episode, 2005
- Niko Nicotera
- Â Messenger 1 episode, 2007
- Federico Pacifici
- Â Veteran Boss 1 episode, 2007
- Giannina Salvetti
- Â Shopkeeper 1 episode, 2007
- Alan Stocks
- Â Andros 1 episode, 2005
- Tom Shaker
- Â Court Lictor 1 episode, 2005
- Ilaria Stivali
- Â Peasant Woman 1 episode, 2005
- Steve Ramsden
- Â Senior Legionary 1 episode, 2005
- Robin Sneller
- Â Cloth Maker 1 episode, 2005
- René Zagger
- Â Herod 1 episode, 2007
- Helen Stirling
- Â Old Weaver 1 episode, 2005
- Sebastiano Vinci
- Â Wild Eyed Man 1 episode, 2005
- Julian Stolzenberg
- Â Bearded Man #2 1 episode, 2007
- Daniel Tatarsky
- Â Timon's Thug 1 episode, 2007
- Steven Blake
- Â Prisoner 1 episode, 2005
- Massimiliano Ubaldi
- Â Ubian #1 (uncredited) 6 episodes, 2005
- Simone De Marinis
- Â Atia's Slave / ... (uncredited) 5 episodes, 2005-2007
- Ilir Jacellari
- Â Roman Solder (uncredited) 2 episodes, 2005-2007
- Robert Dearle
- Â Plague Victim / ... (uncredited) 2 episodes, 2005
- Tommaso Sacco
- Â Centurion (uncredited) 1 episode, 2005
- Silvio Evangelista
- Â Nude man, gift from Atia to Servilia (uncredited) 1 episode, 2005
- Peter Lavin
- Â Additional Voices (uncredited) 1 episode, 2005
- Cesare Cremonini
- Â Arena Hackler (uncredited) 1 episode, 2005
- Giovanni Cianfriglia
- Â Roman Soldier (uncredited) 1 episode, 2005
- Anthony Souter
- Â Marcelus (uncredited) 1 episode, 2005
- Riccardo Antuoni
- Â Ministro (uncredited) 1 episode, 2005
- Federico Torre
- Â Heckler (uncredited) 1 episode, 2005
- Romuald Andrzej Klos
- Â Sentinella (uncredited) 1 episode, 2007
- Marco Pancrazi
- Â Roman Soldier (uncredited) 1 episode, 2007
- Al Mariotti
- Â Tribune (uncredited) 1 episode, 2007
- Maurizio Pulina
- Â Noble Artist (uncredited) 1 episode, 2007
- Umberto De Luca
- Â Torturer (uncredited) 1 episode, 2007
- Lorenzo Tirittera
- Â Fake merchant (uncredited) 1 episode, 2007