- Rebel Wilson
- Stephanie
- Angourie Rice
- Young Stephanie Conway
- Mary Holland
- Martha
- Molly Brown
- Young Martha Reiser
- Sam Richardson
- Seth
- Zaire Adams
- Young Seth Novacelik
- Zoë Chao
- Tiffany
- Ana Yi Puig
- Young Tiffany Blanchette
- Justin Hartley
- Blaine
- Tyler Barnhardt
- Young Blaine Balbo
- Jade Bender
- Bri Loves
- Chris Parnell
- Jim Conway
- Avantika
- Janet
- Joshua Colley
- Yaz
- Jeremy Ray Taylor
- Neil Chudd
- Michael Cimino
- Lance
- Brandon Scott Jones
- Mr. T
- Tiffany Denise Hobbs
- Dr. Jean Johnson
- Lauren Halperin
- Nurse
- Alicia Silverstone
- Deanna Russo
- Lucy Taylor
- Lydia Conway
- Merrick McCartha
- Principal Young
- Ruby Frankel
- Drunk Person
- Steve Aoki
- Steve Aoki
- John Crow
- News Anchor
- Mimi Gould
- Movie Goer
- Vance Kanell
- Usher
- Joel Ray Ishman
- Chemistry Teacher
- Vee Bhakta
- Janet's Dad
- Leonard R. Butler
- Mr. Beenbaum
- James Millar
- Stoner Student Dax
- Darrell Snedeger
- Deanna Russo's Husband
- Alyssa Mae Clark
- Young Deanna Russo
- Jordan Burgess
- Preppy Girl
- Sophie Pittman
- Cheersquad Dancer
- Jerome Beazer
- Stoner Bro
- Marissa Bennett
- Graduating Student
- Andzelika Bobrova
- Student
- Grayson Brooks
- Student / Blaine's Best Friends (uncredited)
- Ryan Austin Bryant
- High School Student
- Gino Cosculluela
- 2022 Cheer Squad
- Molly Cravens
- Tik-Tok Performer
- Natalie Ruth Davis
- Ex Fiancé
- Chance Dollard
- Student
- Lyle Epps
- Pep Rally Student / High School Graduate (uncredited)
- Soniliz Espina
- Student
- Earrien Freeman
- Blaine's Friend
- John Gettier
- Monroe Police Officer
- Naomi Glatzer
- High School Student
- Bella Gracely
- High School Student
- Alex D. Jennings
- Prom Attendee
- Sarah Anne Kauffman
- High School Student
- Jamie Michelle Kelley
- Mascot Billy the Bulldog
- Tyler Kline
- Mullet Bowler
- Jul Kohler
- Russian Nurse
- Daphne Matthews
- Graduation Attendee
- Amelia McArthur
- High School Student
- Zo'Anne Mckinstry
- Teacher
- Taylor McManus
- Prom Attendee
- Danilo Mejia
- High School Graduate
- Joseph B Morman
- Nurse / Student (uncredited)
- Kerstyn Murray
- Bowling Alley Teen
- Kimi Price Queguiner
- Proud Mom Graduation
- Livisha Renee
- Prom Goer
- Sage Shirley
- Bowling Alley Teen
- Tyriq Withers
- Basketball Bro
- Sam Zheng
- Highschool Student