- Markham Anderson
- Colonel John Blade
- Shelley Calene-Black
- Jennifer "JC" Armack
- Chris Patton
- John "JC" Armack
- Sian Taylor
- Elexis Sinclaire
- Andy McAvin
- Vincenzo Manchini
- LaTeace Towns-Cuellar
- Kait Palmer
- Vic Mignogna
- Tim Perko
- Danielle Kimball
- Elyse Stewart
- Ted Pfister
- Lorenzo Vitello
- David Parker
- Dr. Daniel Greenwall
- Jocelyn Donegan
- Tina Vansant
- Hilary Haag
- Skycity Announcer / Mutant Elyse (voice)
- Robert Vellani
- Blade's Father
- Jason Douglas
- Hardcorps Commander / Cop 3 / SinTEK Executive (voice)
- John Swasey
- Cop 1 / Dispatcher 1 / SinTEK Executive (voice)
- Lew Temple
- Cop 2 / Dispatcher 3 / Elyse's Dad (voice)
- Matt Kelley
- Cop 4 / SinTEK Excutive / Reporter (voice)
- Kelly Manison
- Dispatcher 2 / Elyse's Mom / Receptionist / Additional Voices (voice)
- Christopher Bourque
- Dispatcher 4 / Ensign / Additional Voices (voice) (as Lash Bourque)
- Randy Sparks
- Guard / Medic (voice)
- Mike Kleinhenz
- Priest
- Robert Atkins
- Additional Voices
- James Bates
- Additional Voices
- Zak Belica
- Additional Voices
- Mark Dochtermann
- Additional Voices
- Jim Dose
- Additional Voices
- Steven Foster
- Additional Voices
- Richard Gray
- Additional Voices
- Chris Hawley
- Additional Voices
- Tom Mustaine
- Additional Voices
- Andy Orjuela
- Additional Voices
- Sharon Papa
- Additional Voices
- Jason Remmert
- Additional Voices
- Katsuhiro Harasawa
- Reporter
- Masaru Ikeda
- HardCorps Commander
- Kikuko Inoue
- Jennifer Christina 'JC' Armack
- Kôji Ishii
- John Blade
- Hiroya Ishimaru
- John 'JC' Armack
- Masako Katsuki
- Kait Palmer
- Ayako Kawasumi
- Elyse Stewart
- Junji Maruyama
- SinTEK Executive
- Shin'ichirô Miki
- Tim Perko
- Takehiro Murozono
- SinTEK Executive
- Hidekatsu Shibata
- Lorenzo Vitello
- Kaori Yamagata
- Elexis Sinclaire
- Yuriko Yamaguchi
- Tina Vansant
- Naohiro Yamamoto
- SinTEK Executive
- Tamio Ôki
- Dr. Daniel Greenwall
- Akio Ôtsuka
- Vincenzo Mancini