- Gianluca Holder
- Peter Parker / Spider-Man (voice)
- Fritz Ethan Holst
- Wilson Fisk / Kingpin (voice)
- Alexandra Ghabour Haroun
- Mary Jane Watson
- Hanya Tawfeek
- Gwen Stacy
- Hamza Khalil
- Norman Osborn / Green Goblin (voice)
- Driss Jennane
- Tim Harrison
- Ichrak Jennane
- Aunt May / Mrs. Harrison (voice)
- Jared Rautenbach
- Harry Osborn
- John Kennedy
- Dr. Curt Connors
- Massimiliano Siotto
- Rhino
- Ibrahim Aranout
- Gang Member 1
- Ali El Habti
- Gang Member 2
- Cliff Robertson
- Uncle Ben
- Jad Saad
- Fisk Thug
- Tufan Tkurkcuoglu
- Cop
- Adam Fereisah
- Hospital Worker 1
- Leen Wardeh
- Hospital Worker 2
- Walid Hamdan
- Electro
- Lily Hamouda
- Dr. Octopus
- Yasser Gazal
- Danny Rand
- AbdulRahman Dajani
- EMT 1
- Izziddin Farsakh
- EMT 2
- Zakaria El Hallak
- Reed Richards
- Aya El Habti
- Mother Victim
- Judy Ahmed
- Star Receptionist
- Enzo Espitalier
- Jay Jonah Jameson
