- Tim Daly
- Superman / Clark Kent (voice)
- Dana Delany
- Lois Lane
- Clancy Brown
- Lex Luthor
- Malcolm McDowell
- John Corben
- Christopher McDonald
- Jor-El
- Finola Hughes
- Lara
- Mike Farrell
- Jonathan Kent
- Shelley Fabares
- Martha Kent
- Tony Jay
- Sul-Van
- Corey Burton
- Brainiac / Councilman / Cop (voice)
- George Dzundza
- Perry White
- David Kaufman
- Jimmy Olsen
- Lauren Tom
- Angela Chen
- Jesse Batten
- Baby Kal-El
- Brad Garrett
- Bibbo
- Brian George
- Councilman
- Dorian Harewood
- Ron Troupe
- Charles Howerton
- Whirly Pilot / Hans - Terrorist Guard (voice)
- Tress MacNeille
- Ms. Stevenson / Annie's Mother / LexCorp Presenter (voice)
- Jason Marsden
- Teenage Clark Kent
- Roger Rose
- Driver Cop / Councilman (voice)
- Nick Savalas
- Attorney
- Kelly Schmidt
- Lana Lang
- Miracle Vincent
- Danitra Evans / Annie (voice)
- Vernee Watson
- Female Worker / Councilwoman (voice) (as Vernee Watson-Johnson)
