- Christina Aguilera
- Self
- Fred Armisen
- Lawrence Welk / Various (archive footage)
- Dan Aykroyd
- Beldar Conehead / Various (archive footage)
- Alec Baldwin
- Various
- Charles Barkley
- Mr. Jergs
- Candice Bergen
- Fern
- Josh Brolin
- Various
- Gabriel Byrne
- Priest
- Chevy Chase
- Weekend Update Anchor
- Andy Cohen
- Self
- Jane Curtin
- Prymaat Conehead / Weekend Update Anchor / Various (archive footage)
- Rachel Dratch
- Self / Debbie Downer / Abe Scheinwald / Various
- Nora Dunn
- Self / Liz Sweeney / Dorothy / Various
- Abby Elliott
- Various
- Jimmy Fallon
- Various
- Chris Farley
- Tom Arnold
- Will Ferrell
- Ted Nettters / Craig Buchanan / Alex Trebek / Various (archive footage)
- Tina Fey
- Self / Daisy De la Hoya / Sarah Palin / Various
- Will Forte
- Greg Allman / Various (archive footage)
- Ana Gasteyer
- Self / Celine Dion / Martha Stewart / Margaret Jo McCullin / Various
- Bill Hader
- Various
- Darrell Hammond
- Various
- Phil Hartman
- Various
- Salma Hayek
- Adriana
- Jan Hooks
- Self / Candy Sweeney / Greta Garbo / Brenda / Various
- Victoria Jackson
- Roseanne
- Ashton Kutcher
- Various
- Lindsay Lohan
- Various
- Julia Louis-Dreyfus
- Self / Various
- Tim Meadows
- Various
- Seth Meyers
- Various / Weekend Update Anchor (archive footage)
- Bobby Moynihan
- Various
- Eddie Murphy
- Gumby
- Bill Murray
- Richard Dawson / Various (archive footage)
- Laraine Newman
- Self / Connie Conehead
- Cheri Oteri
- Self / Nadeen / Arianna / Barbara Walters / Various
- Chris Parnell
- Simon Cowell / Various (archive footage)
- Amy Poehler
- Self / Betty Caruso / Sharon Osbourne / Michael Jackson / Amber / Hillary Clinton / Various
- Gilda Radner
- Emily Litella / Various (archive footage)
- Maya Rudolph
- Self / Donatella Versace / Whitney Houston / Jodi Deitz / Oprah Winfrey
- Andy Samberg
- Various
- Horatio Sanz
- Uncle Frank / Various (archive footage)
- Molly Shannon
- Self / Monica Lewinsky / Mary Katherine Gallagher / Sally O'Malley / Courtney Love / Terry Rialto / Various
- Jenny Slate
- Gretchen
- Snoop Dogg
- Self
- Jason Sudeikis
- Bret Michaels / Various (archive footage)
- Julia Sweeney
- Pat
- Kenan Thompson
- Randy Jackson / Various (archive footage)
- Christopher Walken
- Various
- Michaela Watkins
- Hoda Kotb / Various (archive footage)
- George Wendt
- Dominick
- Betty White
- Florence Dusty
- Kristen Wiig
- Self / Suze Orman / Jamie Lee Curtis / Aunt Linda / Shana / Kathie Lee Gifford / Target Lady / Dooneese / Peyton Turner / Penelope / Various
- Casey Wilson
- Kristy Joe Muller / Nora / Annie / Various (archive footage)
- Josh Truesdell
- Man Servant
