- Bill Leff
- Â Bill the Cartoon Curator / ... 864 episodes, 2021-2025
- Kevin Fleming
- Â Toony the Tuna / ... 863 episodes, 2021-2025
- Leila Gorstein
- Â Goldie Fisher / ... 345 episodes, 2021-2024
- Yazmin Ramos
- Â Sockeye Sam / ... 57 episodes, 2022-2023
- Rich Koz
- Â Kerwyn / ... 41 episodes, 2021-2024
- Brent DiCrescenzo
- Â Hot Dog / ... 10 episodes, 2022-2024
- Jerry Beck
- Â Self - Cartoon Historian / ... 6 episodes, 2021-2024
- Eric Bauza
- Â Eric Bauza / ... 3 episodes, 2022-2024
- Adam Manta
- Â Gorilla / ... 3 episodes, 2022-2023
- Emily Kaufman
- Â Emily Kaufman / ... 2 episodes, 2023-2024
- Jeff Bergman
- Â Self - 'Bugs' Voice Artist 3 episodes, 2021
- Jamie Schiller
- Â Donkey / ... 3 episodes, 2022-2023
- Meggie Armstrong
- Â Film Crew Member / ... 2 episodes, 2022-2023
- Bill Mumy
- Â Self / ... 2 episodes, 2021-2023
- Dominique Leach
- Â Chef Dominique Leach - Chef & Pitmaster, Lexington Betty Smokehouse / ... 2 episodes, 2023-2024
- Debi Lilly
- Â Debi Lily / ... 1 episode, 2024
- Paul Mackey
- Â Dude / ... 2 episodes, 2021-2023
- Bill Kurtis
- Â Bill Kurtis - Renowned Journalist / ... 1 episode, 2022-2023
- Lisa Whelchel
- Â Lisa Welchel 2 episodes, 2023-2024
- Jacob Cromwell
- Â Jacob - Bouncer / ... 1 episode, 2023-2024
- Gilbert Gottfried
- Â Self 2 episodes, 2021
- Ruth Clampett
- Â Ruth Clampett / ... 2 episodes, 2021-2023
- Robert McKimson Jr.
- Â Self - Robert McKimson's Son 2 episodes, 2021
- Mark Fleischer
- Â Mark Fleischer - Fleischer Studios / ... 2 episodes, 2023
- Briana Janczy
- Â Briana / ... 1 episode, 2023
- Jim Louderman
- Â Jim Louderman - The Field Museum 2 episodes, 2024
- Leo Benvenuti
- Â Self - Special Guest 1 episode, 2022
- Fee Basanavisius
- Â Fee Basanavisius - Guest Comedian 1 episode, 2023
- Lanny Smoot
- Â Lanny Smoot - Disney Imagineer 1 episode, 2024
- Bela Gandhi
- Â Bela Gandhi - Founder, Smart Dating Academy 1 episode, 2024
- Bethany Pickens
- Â Bethany Pickens - Jazz Pianist & Composer 1 episode, 2024
- Ryan Freeman
- Â Ryan Freeman - Balloon Artist 1 episode, 2024
- Chris Murphy
- Â Chris Murphy - Junebug Cafe 1 episode, 2024
- Jeff Warren
- Â Jeff Warren - Meditation Teacher 1 episode, 2024
- Derrick Tung
- Â Derrick Tung - Owner, Paulie Gee's Chicago 1 episode, 2024
- Akilah Siti Easter
- Â Akilah Siti Easter - Etiquette Expert 1 episode, 2024
- Yakov Smirnoff
- Â Self 1 episode, 2021
- Analise Ockenfels
- Â Wind Wrangler 1 episode, 2021
- Robert Rodi
- Â Elephant 1 episode, 2021
- Marissa Chastain
- Â Marissa Chastain - Guest Comedian 1 episode, 2023
- Sarah Palmer
- Â Gwengoolie 1 episode, 2024
- Mona Marshall
- Â Mona Marshall - Voice Actor 1 episode, 2024
- Scott Gryder
- Â IMP 1 episode, 2024
- Angela Cartwright
- Â Self - Co-Author, 'Lost (and Found) in Space 2' 1 episode, 2021
- Dawn Wells
- Â Self - Voice Message 1 episode, 2021
- Billy West
- Â Self - 'Bugs' Voice Artist 1 episode, 2021
- Kimberly
- Â Self - Super-Tooner 1 episode, 2021
- Mandy Scott
- Â Self - Super-Tooner 1 episode, 2021
- Clinton Robison
- Â Self - Super-Tooner 1 episode, 2021
- Claire
- Â Self - Super-Tooner 1 episode, 2021
- Nanette Keir
- Â Self - Super-Tooner 1 episode, 2021
- Allison
- Â Self - Super-Tooner 1 episode, 2021
- Sarah Rhodes
- Â Self - Super-Tooner 1 episode, 2021
- Christopher Hamby
- Â Self - Super-Tooner 1 episode, 2021
- Shelly Martinez
- Â Self - Super-Tooner 1 episode, 2022
- Cheryl Chase
- Â Self 1 episode, 2022
- Drew Love
- Â Self - Super-Tooner 1 episode, 2022
- Mason Burchett
- Â Self - Super-Tooner 1 episode, 2022
- Gregory Litchfield
- Â Self - Super-Tooner 1 episode, 2022
- Sketch Carney
- Â Self - Super-Tooner 1 episode, 2022
- Jim Engel
- Â Self 1 episode, 2022
- Gary Tucker
- Â Self - Super-Tooner 1 episode, 2022
- Oscar
- Â Self - Super-Tooner 1 episode, 2022
- Jasmine Amy Rogers
- Â Jasmine Amy Rogers - Betty Boop, Boop! the Musical 1 episode, 2023
- Eddie Korosa
- Â Eddie Korosa Jr. - Accordionist 1 episode, 2023
- Jerry Mitchell
- Â Jerry Mitchell - Director + Choreographer, Boop! The Musical 1 episode, 2023
- Bill Cochran
- Â Narrator 1 episode, 2023
- Carolyn Caruso Jollette
- Â Carolyn Caruso Jollette - Chicago Honey Bear 1 episode, 2023
- Debbie Lemons Nichol
- Â Debbie Lemons Nichol - Chicago Honey Bear 1 episode, 2023
- Chelsea Matkins
- Â Chelsea Matkins - Gen Z 1 episode, 2023
- John McInerney
- Â John McInerney - Gen X 1 episode, 2023
- Michellise Lawson
- Â Michellise Lawson - Chicago Honey Bear 1 episode, 2023
- Malvina De Salvo
- Â Malvina De Salvo - Millennial 1 episode, 2023
- Jean Twenge
- Â Jean Twenge - Author of 'Generations' 1 episode, 2023
- Fred Weichman
- Â Fred Weichman - Boomer 1 episode, 2023
- Andrew Meland
- Â Andrew Meland - Urban Canopy 1 episode, 2023
- Tom D. Jones
- Â Tom Jones - Veteran NASA Astronaut & Spacewalker 1 episode, 2023
- Patti Ross
- Â Patti Ross - Chicago Honey Bear 1 episode, 2023
- Andrea Ghidara
- Â Andrea Ghidara - Chicago Honey Bear 1 episode, 2023
- Katsuji Tanabe
- Â Katsuji Tanabe - Chef 1 episode, 2024
- Chris Blatner
- Â Chris Blatner - Founder, Urban Bourbonist 1 episode, 2024
- Kit Boga
- Â KitBoga - @kitbogashow 1 episode, 2024
- AJ Sacco
- Â AJ Sacco - Magician 1 episode, 2024
- Nicole Johnson
- Â Nicole Johnson - Director of Butterball Turkey Talk-Line 1 episode, 2024
- Aaron Lewis
- Â Aaron Lewis - Sculptor, Zagone Studios 1 episode, 2024
- Jenny Pfanenstiel
- Â Jenny Pfanenstiel - Featured Milliner of the Kentucky Derby 1 episode, 2024
- Juan Hernandez
- Â Juan Hernandez - Marathon Runner 1 episode, 2024
- Jeff Havely
- Â Jeff Havely - Pro Rodeo Clown 1 episode, 2024
- Sally Marvel
- Â Sally Marvel - Sword Swallower 1 episode, 2024
- Michael Zagone
- Â Michael Zagone - Production Manager, Zagone Studios 1 episode, 2024
- Michael Markellos
- Â Michael Markellos - Owner, Philly's Best 1 episode, 2024
- Tony Zagone
- Â Tony Zagone - Co-owner, Zagone Studios 1 episode, 2024
- Derek Dye
- Â Derek Dye - Affy Tapple Director of Marketing 1 episode, 2024
- Caity Gee
- Â Caity Gee - Contortionist 1 episode, 2024
- Max Barajas
- Â Max Barajas - Nadeau's Ice Sculptures 1 episode, 2024
- George Ramirez
- Â George Ramirez - Personal Stylist 1 episode, 2024
- Natalie Gilberto
- Â Natalie Gilberto - Dance Instructor (uncredited) 2 episodes, 2023
- Wendy Snyder
- Â Leticia Donnybrook (uncredited) 1 episode, 2021
- Ryan Nemeth
- Â Ryan Nemeth (uncredited) 1 episode, 2023
- Darrell Sheets
- Â Darrell Sheets (uncredited) 1 episode, 2023
- Samantha Brown-Parks
- Â Sam Brown-Parks MD MPH (uncredited) 1 episode, 2023
- Davon Cecil
- Â Davon Cecil - School Lunch Taster (uncredited) 1 episode, 2023
- Raymond Acevedo
- Â Raymond Acevedo - Former Member of Menudo (uncredited) 1 episode, 2023
- Alexis Walker
- Â Alexis - Hot Chocolate Taster (uncredited) 1 episode, 2023
- Pandora Pappas
- Â Pandora Pappas - Psychic Reader & Clairvoyant (uncredited) 1 episode, 2023
- Beah Travis
- Â Beah (uncredited) 1 episode, 2023
- Patty Lupo
- Â Self - The Caroling Party (uncredited) 1 episode, 2023
- Anthony Valdez
- Â Santa Claus (uncredited) 1 episode, 2023
- La'Tia Owens
- Â La'Tia Owens - School Lunch Taster (uncredited) 1 episode, 2023
- Ron Guinazzo
- Â Chicago Ron - Treasure Hunter (uncredited) 1 episode, 2023
- Patrick Brower
- Â Patrick Brower - Challengers Comics Co-owner (uncredited) 1 episode, 2023
- Nicole Styskun
- Â Nicole Styskun - School Lunch Taster (uncredited) 1 episode, 2023
- Julie Swieca-Gannon
- Â Julie Swieca-Gannon - Pastry Chef (uncredited) 1 episode, 2023
- Chester Jankowski
- Â Self - Senior Horticulturist (uncredited) 1 episode, 2023
- Scott Berman
- Â Scott - Superdawg Drive-In (uncredited) 1 episode, 2023
- Benjamin Barnes
- Â Benjamin Barmes - Magician (uncredited) 1 episode, 2023
- Jaime Gamboa
- Â Jaime Gamboa - Martial Arts Instructor (uncredited) 1 episode, 2023
- Jeff Cole
- Â Jeff Cole - Rockabilly Artists Alliance (uncredited) 1 episode, 2023
- Megan Knee
- Â Megan Knee - Fitness Instructor (uncredited) 1 episode, 2023
- John Fonseca
- Â John Fonseca - Martial Arts Instructor (uncredited) 1 episode, 2023
- Chris Brown
- Â Self - The Caroling Party (uncredited) 1 episode, 2023
- Marc Solomon
- Â Marc Solomon - Master Pumpkin Carver (uncredited) 1 episode, 2023
- Paul Iams
- Â Self - The Caroling Party (uncredited) 1 episode, 2023
- Maddy Kelly
- Â Maddie - Taste Tester (uncredited) 1 episode, 2023
- Kaitlynn Etheridge
- Â Curator, Columbus Collective Museums (uncredited) 1 episode, 2023
- Dorethia Kelly
- Â Dorethia Kelly - Financial Expert (uncredited) 1 episode, 2023
- The Voices of Magic
- Â Themselves - Babershop Quartet (uncredited) 1 episode, 2023
- Sylvia Hernandez-DiStasi
- Â Sylvia Hernandez-DiStasi - Artistic Director, The Actors Gymnasium (uncredited) 1 episode, 2023
- W. Dal Bush
- Â W. Dal Bush - Challengers Comics Co-owner (uncredited) 1 episode, 2023
- Lisa Berman-Drucker
- Â Lisa - Superdawg Drive-In (uncredited) 1 episode, 2023
- Don Drucker
- Â Don - Superdawg Drive-In (uncredited) 1 episode, 2023
- Sam Maranto
- Â Sam Maranto - UFO Investigator (uncredited) 1 episode, 2023
- Phil Zuziak
- Â Phil Zuziak - Mixologist & Owner, Tiki Terrace (uncredited) 1 episode, 2023
- Neal Gibbons
- Â Neal Gibbons - Paranormal Investigator (uncredited) 1 episode, 2023
- Gina Milone
- Â Gina Milone - Co-owner, Country Donuts (uncredited) 1 episode, 2023
- Erin Port
- Â Erin Port - Founder, Simple Purposeful Living (uncredited) 1 episode, 2023
- Allen Woodall
- Â Founder, Columbus Collective Museums (uncredited) 1 episode, 2023
- Tina Reynolds
- Â Self - The Caroling Party (uncredited) 1 episode, 2023
- Billy Gardell
- Â Billy Gardell (uncredited) 1 episode, 2024
- Dan Bakkedahl
- Â Dan Bakkedahl - Podcaster (uncredited) 1 episode, 2024
- Christopher Knight
- Â Christopher Knight - Peter Brady on 'The Brady Bunch' (uncredited) 1 episode, 2024
- Danny Bonaduce
- Â Danny Bonaduce (uncredited) 1 episode, 2024
- Bob Bergen
- Â Bob Bergen - Voice Actor (uncredited) 1 episode, 2024
- Britta Phillips
- Â Britta Phillips - Singing Voice of Jem (uncredited) 1 episode, 2024
- Juan Gutierrez
- Â Chef Juan Gutierrez (uncredited) 1 episode, 2024
- Sarafina Vecchio
- Â Sarafina Vecchio - Acting Coach (uncredited) 1 episode, 2024
- Brenda Chapman
- Â Brenda Chapman - Director and Writer (uncredited) 1 episode, 2024
- Ilene Kristen
- Â Ilene Kristen - Star of Ryan's Hope (uncredited) 1 episode, 2024
- John A. Russo
- Â John Russo - Writer & Producer (uncredited) 1 episode, 2024
- John Naber
- Â John Naber - U.S. Olympic Hall of Fame (uncredited) 1 episode, 2024
- Jenny Hagel
- Â Jenny Hagel - Comedian and Late Night Writer (uncredited) 1 episode, 2024
- Ayoka Chenzira
- Â Ayoka Chenzira - Filmmaker (uncredited) 1 episode, 2024
- Saran Dunmore
- Â Saran Dunmore - Fitness Expert (uncredited) 1 episode, 2024
- Joe Canale
- Â Joe Canale - Podcaster (uncredited) 1 episode, 2024
- Craig Kausen
- Â Craig Kausen - Grandson of Chuck Jones (uncredited) 1 episode, 2024
- Neal Sabin
- Â Neal Sabin - Vice Chairman, Weigle Broadcasting (uncredited) 1 episode, 2024
- Freshman Fifteen
- Â Themselves - A Capella Vocal Group (uncredited) 1 episode, 2024
- Chef Lala
- Â Chef Lala - Celebrity Chef & Nutritionist (uncredited) 1 episode, 2024
- Elliott From
- Â Elliott From - Speed Painter (uncredited) 1 episode, 2024
- Eugenia Cheng
- Â Dr. Eugenia Cheng - Author and Mathematician (uncredited) 1 episode, 2024
- Bethany Bey
- Â Bethany Bey - Chicago Gardener (uncredited) 1 episode, 2024
- Kevin Johnson
- Â Kevin Johnson - River Valley Survival (uncredited) 1 episode, 2024
- Samantha Hochmann
- Â Samantha Hochmann - Executive Director, Tinker Swiss Cottage Museum & Gardens (uncredited) 1 episode, 2024
- Olivia Bonocore
- Â Olivia Bonocore - Food Taster (uncredited) 1 episode, 2024
- Alisha Elenz
- Â Alisha Elenz - Chef (uncredited) 1 episode, 2024
- Erik Perez
- Â Erik Perez - Production Intern (uncredited) 1 episode, 2024
