High school soccer players from across Japan gather for a controversial project designed to create the best and most egoistic striker in the world.

Japan keeps losing the World Cup, over and over. After Isagi Yoichi, a forward for a high school team, gets eliminated in the last game in the qualifier for nationals, gets invited to a program called "Blue Lock" Their coach will be Ego Jinpachi, who intends to "destroy Japanese loser football" by introducing a radical new training regimen: isolate 300 young forwards in a prison-like institution called "Blue Lock" and put them through rigorous training aimed at creating "the world's greatest egotist striker."