The program focuses on the misadventures of two unlikely yet somehow biological siblings: Cow and Chicken.

A scrawny, 11-year-old chicken named Chicken reluctantly watches out for his beefy "little" sister, a 7-year-old cow named Cow. The unconventional offspring of two human parents, the two young animals navigate their way through suburbia, encountering problems not only at school, but with the devilish schemes of the Red Guy, a crimson-colored antagonist of many guises whose singular intent is to make the siblings' lives miserable. If the character design and offbeat humor of "Cow and Chicken" cause viewers to recall "The Ren & Stimpy Show (1991)" there's a good reason: creator David Feiss worked on that irreverent animated series as well.