Follows Special agent Avery Ryan as she works to solve internet related crimes as a cyberpsychologist for the Cyber crimes division of the Federal Bureau of Investigation (FBI).

The fourth installment in the "CSI" franchise takes inspiration from the advanced technological work of a real cyberpsychologist named Mary Aiken. Avery Ryan heads the FBI's Cyber Crime Division, a unit at the forefront of solving illegal activities that live online and play out in the real world. While other agents search for criminals in the streets, Avery knows how technology allows people to hide in the shadows of the Internet while committing serious crimes, and she spends her time searching the deep recesses of the Web where anonymity protects, money is less-traceable, and almost anything imaginable is up for sale.