A supermodel is attacked by a monster which brings her inner devil out. However, she doesn't let go of her humanity, so a secret government agency asks her to help them fight the demonic forces that secretly threaten Japan and the world.

Fudo Jun is a beautiful supermodel who is idolized by many. She also has a dark secret that not even she knows about at first, for within her veins run the genes that hold the next step in the evolution of mankind. The same blood as the beast like super humans that terrorize the city. Unlike the rest of them, though, Jun has managed to hold a tenuous grip onto her humanity, and she is recruited by the mysterious Asuka Ran, member of a secret organization within the government, aimed at controlling, if not eliminating, these berserk destroyers of mankind. Jun, as Devilman Lady, must now exterminate her own kind, but how much longer can she keep her sanity in a situation she never chose in the first place?—ANN