Dojin Work follows a girl named Najimi Osana and her exposure to the amateur manga world.

Najimi Osana was first tempted into becoming a amateur manga artist after seeing how much one of her friends can make at a convention. Najimi loves to draw, though soon learns contrary to what she expected that this new world is anything but easy. As she attends more conventions and meets more people, Najimi eventually manages to find a group of interesting friends. These friends already have some experience in the field and help her out along the way so that she can someday make a name for herself creating manga.