A year after defeating Masamune (Kamen Rider Cronus), Emu Hojo and the Doctor Riders venture into the VR Game World to deal with a new Game Disease outbreak hitting Tokyo.

An evil ninja Rider, Kamen Rider Fuma, appears from the virtual reality world in an effort to conquer Earth. It is up to the CR Riders to use the power of virtual reality gaming to save a young girl's life and stop the evil plans of Machina Vision CEO Johnny Maxima before the Bugster Virus infects all of humanity.