Young writer Sal Paradise has his life shaken by the arrival of free-spirited Dean Moriarty and his girl, Marylou. As they travel across the country, they encounter a mix of people who each impact their journey indelibly.

Shaken by the death of his father and discouraged by his stalled career, writer Sal Paradise goes on a road trip hoping for inspiration. While traveling, he is befriended by charismatic and fearless Dean Moriarty and Moriarty's free-spirited and seductive young wife, Marylou. Traveling across the American southwest together, they strive to break from conformity and and search the unknown, and their decisions change the very course of their lives.—anonymous

In 1947 New York, on the day his father is buried, Sal Paradise is out with his friend Carlo Marx who is, like him, an aspiring writer. They're invited by mutual friend Chad to meet Dean Moriarty, a young car thief from Denver, and Dean's 16-year-old wife Marylou. Sal and Carlo befriend Dean, smoking marijuana with him and visiting a jazz nightclub where they meet saxophonist Walter, who also befriends them. Sal teaches Dean how to write before Dean leaves for Denver with Carlo. After much contemplation, writer's block, and a solemn visit to his father's grave, Sal decides to join his friends in Denver and embarks on the road for the first time. There, Sal meets Camille, an art college student for whom Dean is divorcing Marylou. Carlo starts to question his sexuality, and Carlo and Dean start an affair..