The causes and consequences of America's opioid epidemic unfold in this drama following its perpetrators, victims and an investigator seeking the truth.

Painkiller exposes the roots of the most pressing health epidemic of the 21st century. Powerful narcotic painkillers, or opioids, were once used as drugs of last resort for pain sufferers. Purdue turned OxyContin into a billion dollar blockbuster by launching an unprecedented marketing campaign claiming that the drug's long-acting formulation made it safer to use than traditional painkillers for many types of pain. That illusion was quickly shattered as drug abusers learned that crushing an Oxy could release its narcotic payload all at once. Even in its prescribed form, Oxy proved fiercely addictive. As OxyContin's use and abuse grew, Purdue concealed what it knew from regulators, doctors, and patients.