Three disillusioned women in their 20s with superpowers who used to fight crime together and now resent having lost their childhood to that are faced with the choice of reuniting now that the world needs them more than ever.

A live-action reboot of the 1998 cartoon The Powerpuff Girls (1998), set a couple decades into the girls' future. The titular trio, formed by Blossom, Buttercup and Bubbles, are now disillusioned women in their twenties who resent having lost their childhood to crime-fighting. Now, they are faced with the choice of reuniting and going back to crime-fighting together, as the world needs them now more than ever.