In order to help a friend possessed by a spirit, Ozawa Haruka knocks on the door of her university's movie research association. There she meets Saitou Yakumo, a rude, unkempt young man with a red left eye, who is said to have spiritual powers. At first Haruka is skeptical, but she comes to believe him when he conveys messages from her older sister, who died when she was a child. Together, they work to shed light on the terrifying events happening at their university. But this is only the prologue of what's to come...—ANN

Haruka Ozawa's sophomore year is getting seriously scary. One of her friends is possessed, another has committed suicide and Haruka could be the next one to flunk the still-breathing test. So, what's her only way out of this potentially lethal dead end? Yakumo Saito, an enigmatic student born with a mysterious red eye that allows him to see and communicate with the dead. But the deceased don't always desist and some killers are more than ready to kill again to keep dead men from telling any more tales. That doesn't stop Haruka's knack for digging up buried secrets, and there's even more evidence of bodies being exhumed by both Yakumo's police contact and an investigative journalist with a newly made corpse in her closet. Can this pair of anything but normal paranormal detectives solve the ultimate dead case files or will they end up in cold storage themselves? If the spirits are willing, they may just have a few ghosts of a chance in PSYCHIC DETECTIVE YAKUMO!.—Section 23

College student Haruka's life takes a disturbing turn when a night of innocent fun turns horrific. After one friend commits suicide and another becomes possessed, Haruka reaches out to the enigmatic Yakumo Saito, a fellow student who is rumored to have psychic powers. But beneath the dubious claims surrounding Yakumo is a dark secret concerning his mysterious red eye and the souls of the dead. Haruka's case is only the beginning of a supernatural storm that will put them both to the test!.—Sentai Filmworks

Saitou Yakumo is a college student who was born with different eye colours. His red left eye gives him a special ability to see ghosts and spirits. He believes ghosts and spirits are bound to earth because of a certain cause, and simply eliminating that cause will let those spirits rest in peace. Being asked for help by Ozawa Haruka, they begin the investigation together.—AniDB