Teresa flees Mexico after her drug-runner boyfriend is murdered. Settling in Dallas she looks to become the country's reigning drug smuggler and to avenge her lover's murder.

Queen of the South tells the powerful story of Teresa Mendoza, a woman who is forced to run and seek refuge in America after her drug-dealing boyfriend is unexpectedly murdered in Mexico. In the process, she teams up with an unlikely figure from her past to bring down the leader of the very drug trafficking ring that has her on the run.