Después de ser derrotado por el mago Cristaldi, Drácula regresa para vengarse del Santo y Blue Demon contra Drácula y el Hombre Lobo. Con la ayuda del Hombre Lobo y sus seguidores, la victoria es inminente. Un descendiente del Mago Cistaldi es advertido de los planes de Drácula y pide ayuda a Santo y Blue Demon.

Masked wrestling champion and occasional crime fighter El Santo once again saves Mexico from the ravages of undying monsters in this blend of grappling and horror. El Santo is challenged to a match by fellow wrestler El Angel Blanco, and while the great fighter is busy in the ring, two legendary monsters, the vampire Dracula (Aldo Monti) and a werewolf named Rufus Rex (Agustin Martinez Solares) are brought back to life by his enemies. As the monsters roam free and threaten the life of El Santo's closest friends, he teams up with fellow wrestling icon Blue Demon to vanquish the creatures once and for all.