Kraft Lawrence goes from town to town to make profits as a travelling merchant, with the help of a wolf deity by the name of Holo.

Kraft Lawrence, a 25 year old peddler travelling from town to town selling and buying various things to make a living during a period much like Europe in the Middle Ages. One night when stopped at the town of Pasroe, he finds in his wagon a 250 year old pagan wolf deity girl named Holo. She appears to be that of a 15 year old girl, except for a wolf tail and ears. She introduces herself as the town's goddess of harvest who has kept it blessed with good harvests of wheat for many years. Despite having the responsibility to watch over the town, she wants to go back to her homeland in the north called Yoitsu, she believes the people have already forsaken her anyway and that she has kept her promise to maintain the good harvests. She manages to bargain her way out of the village by making a deal with Lawrence to take her with him. As they travel, her wisdom helps increase his profits, but at the same time, her true nature draws unwanted attention from the church.—Anonymous

Continuing from the first series, it follows Kraft Lawrence an experienced traveling merchant and his sharp tongued wolf goddess companion Holo on their journey to return to Holo's home to the north called Yoitsu. They make deals, travel between cities, encounter religious fanatics and mostly just do what they have to do to get by.—Tyraye

Spice and Wolf focuses on the story of a wandering merchant named Kraft Lawrence. The story takes place in the medieval period, at the time when danger was awaiting you at every corner and turn: outlaws, different deadly illnesses, and church, which was the number 1 issue for many-- a misstep and you become a heretic. Kraft Lawrence has been wandering for 7 years already, trying to earn enough money to open his own shop and to become a better merchant. When he leaves another small village to sell goods, he finds the Goddess of harvest in his wagon. Horo explains the merchant that people no longer need her help and are starting to forget about her: they neither pray to her, nor do they even remember about her lending a helping hand to them when they needed it. And after a little test, the merchant agrees to take the Goddess on his journey. Who would refuse to have a Goddess on your side?—Scientiiaa