In 1930s Chicago, Frankenstein asks Dr. Euphronius to help create a companion. They give life to a murdered woman as the Bride, sparking romance, police interest, and radical social change.

A lonely Frankenstein travels to 1930s Chicago to seek the aide of a Dr. Euphronius in creating a companion for himself. The two reinvigorate a murdered young woman and the Bride is born. She is beyond what either of them intended, igniting a combustible romance, the attention of the police and a wild and radical social movement.