Siblings Roderick and Madeline Usher have built a pharmaceutical company into an empire of wealth, privilege and power; however, secrets come to light when the heirs to the Usher dynasty start dying.

The Usher family is never far from controversy. The fortunes of siblings Roderick and Madeline Usher were made through Fortunato Pharmaceuticals, a company whose products are often under scrutiny due to health concerns. Assistant District Attorney C. Auguste Dupin is determined to land a conviction and his case against Fortunato and the Ushers has gone to trial. Now, right in the middle of the trial, Roderick's children are dying under mysterious circumstances. Roderick Usher knows who/what is behind the deaths and meets with Dupin to reveal all.—grantss

The story of The Fall of the House of Usher starts in November 2023, right after Roderick Usher, the wealthy and powerful CEO of corrupt pharmaceutical company Fortunato Pharmaceuticals, lost all six of his children - from oldest to youngest: Frederick, Tamerlane (the only two not born from different mothers or outside marriage), Victorine, Camille, Napoleon and Prospero - within two weeks. The evening after the final funeral for his children, Roderick invites C. Auguste Dupin, an Assistant United States Attorney who dedicated his career to exposing Fortunato Pharmaceuticals' corruption, to Roderick's childhood home, where he tells Dupin the true story of his family and gradually unveils the Ushers' darkest secrets. The series follows two timelines in addition to the conversation between Roderick and Dupin, depicted onscreen when told by Roderick: the first, taking place from 1953 to 1980, recounts Roderick and his twin sister Madeline's youth and subsequent rise to power, while the second follows all of the Ushers during the two weeks leading up to the discussion, revealing the truth behind the deaths of Roderick's children.