Not wanting to live in the shadows any longer, Winnie-the-Pooh, Piglet, Owl, and Tigger take their fight to the town of Ashdown, leaving a bloody trail of death and mayhem in their wake.
"Deep within the 100-Acre-Wood, a destructive rage grows as Winnie-the-Pooh, Piglet, Owl, and Tigger find their home and their lives endangered after Christopher Robin revealed their existence. Not wanting to live in the shadows any longer, the group decides to take the fight to the town of Ashdown, home of Christopher Robin, leaving a bloody trail of death and mayhem in their wake. Winnie and his savage friends will show everyone that they are deadlier, stronger, and smarter than anyone could ever imagine and get their revenge on Christopher Robin, once and for all."
After their rampage in the Hundred Acre Wood, Pooh and his friends venture into the town of Ashdown, seeking revenge on Christopher Robin. They embark on a bloody killing spree, terrorizing the town's residents and leaving a trail of carnage in their wake. As the body count rises, Christopher Robin must confront his past and stop the murderous rampage of his once-beloved friends.—Oscar Serpa
Christopher Robin flees from the Hundred Acre Wood after surviving Winnie-the-Pooh's and Piglet's killing spree. He returns to his childhood town of Ashdown to seek for help; the corpses of Maria and her friends are recovered from the woods, but Christopher is believed to be responsible.
The incident is dubbed as the "Hundred Acre Massacre", with a film adaptation based on the murders being released, which damages Christopher's reputation in Ashdown. Now an outcast of the town, Christopher has nightmares about Pooh and goes to his hypnotherapist Samantha to deal with a childhood trauma when his twin brother Billy was kidnapped and never seen again.
Meanwhile, in the Hundred Acre Wood, Pooh, Piglet, and fellow creatures Tigger and Owl, are forced to hide due to a few people who believe in Christopher's story. After they slaughter three university students in a recreational vehicle, Owl convinces Pooh to attack Ashdown instead of simply waiting for more people to come to the woods. When some hunters ambush the creatures and fatally shoot Piglet, Pooh kills them in retaliation and reconsiders Owl's proposal.
Christopher loses his job as a doctor and returns to undergo further hypnotherapy with Samantha. He learns that only a hunter survived and was hospitalized. Christopher also meets Cavendish, the hospital's janitor, and confronts him about the creatures. Cavendish reveals that he worked for Dr. Arthur Gallup, a scientist who forced him to kidnap children around Ashdown for experiments with animal genes. The children did not survive and were buried in the Hundred Acre Wood, where they came back as half-animal, half-human hybrids with an enhanced healing factor. When Cavendish also admits that Billy was among the victims and was resurrected as Pooh, he commits suicide out of guilt.
Christopher warns the town about the creatures' imminent attack, but faces ridicule and skepticism. Pooh, Tigger, and Owl embark on a murderous rampage through Ashdown and kill several residents on the way, including Christopher's best friend Finn. Pooh personally kills Christopher's parents Alan and Daphne and kidnaps his younger sister Helen, nicknamed Bunny, while Christopher's girlfriend Lexy is also attacked but survives. The creatures arrive to a rave party at a warehouse and slaughter all the partygoers. Christopher and Lexy kill Tigger and learn that Bunny was kidnapped. They return to the Hundred Acre Wood and fight Pooh, who easily subdues them both. When Christopher calls Pooh by his real name, Billy, he tries to remember his childhood but accuses him of abandoning the creatures, leading to Eeyore being cannibalized in the past.
Christopher is forced to kill Pooh with an axe before he reunites with Lexy and Bunny. Footage from the creatures' killing spree on Ashdown is passed to the police, and Christopher is cleared of all wrongdoing. Owl, having survived, recovers the bodies of Pooh, Tigger, and Piglet, and promises to find a way to revive them with the help of some old friends. Drawings from Bambi, Peter Pan, and Pinocchio are seen in the end credits.
