Set in the period before establishment of PRC. Bilharziasis wreak havoc in Jiangxi Province and couple Fang move the family to Zhejiang Province, but the new place is unfortunately also an severely afflicted area. Father Fang dies quickly, the son is conscripted, and his child bride marries other people under desperation. After the establishment of PRC, the poor bride's husband dies of bilharziasis and she is also afflicted with the suffer. When Fang's son returns and knows the bride's suffering, he decides work with his mother to help the bride to defeat the pandemic disease.