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Families, friends, enemies, and lovers experience life-changing events in the large upstate city of Port Charles, New York, which has a busy hospital, upscale hotel, cozy diner, and dangerous waterfront frequented by the criminal underworld.

An original medical murder mystery surrounding an unknown killer coccus (bacteria), that leaves no trace in the victim's body, which enables it to be used as the perfect weapon to kill. Fujimaki Tatsuomi is a pathologist working at the Pathlogy department at Meikyo Medical University Hospital. He's looked down upon by the other staff around him and his relationship with Maho his wife, a former nurse, has cooled down. After a patient's suspicious death, he makes a new discovery; when the deadly bacteria "Gift" invades the body, the patient soon dies but the "Gift" leaves no trace thereafter, enabling it to be used as the perfect weapon to kill. As a result of this discovery, Fujimaki's life dramatically changes. While searching for a way to treat his ailing wife's heart disease, he becomes embroiled in a conspiracy surrounding the killer bacteria "Gift."

Dr. Megan Hunt was a brilliant neurosurgeon at the top of her game until a devastating car accident ended her time in the operating room. But rather than end her medical career, Megan becomes a medical examiner.

When the respected Dr. Lucinda Edwards loses an opioid overdose patient, she faces an investigation probing into her conduct that night.

Harrow tells the story of Dr. Daniel Harrow, a forensic pathologist with a total disregard for authority.

Two well-established families get embroiled in a complicated struggle rooted in grief, anger, and a passionate desire for revenge. The husbands and wives set their elaborate plans in motion as they fight for their loved ones and their own desires.