When magic makes its way from Witch World into the human world, Sabrina must protect her best friend, Harvey, who is forever changed by it as he is turned into a savagely violent werewolf every full moon.
Enchantra puts a dark curse on the red roses Sabrina brings to school to give to her human friends on Valentine's Day. With Veralupa's help, Sabrina must gather all of the snarling fanged roses to keep her human friends safe from being eaten alive.
When Sabrina has both a school play and a witch battle with her and her cousin Ambrose against an Ice Giant on the same night, her friendship with Jessie - the only human that knows that she is a witch - is put to the test; especially with Enchantra's arrogant son, Shinji, running interference during the battle.
Sabrina is in charge of finding a band for a benefit concert in Greendale, but Shinji's plans to put together his own band in Witch World makes Sabrina's job much more difficult.
When Shinji kidnaps a baby dragon during a class assignment, it gets loose in the human world with a bad case of fiery hiccups in the form of fireballs. Sabrina must find and return it to its mother, who is angrily attacking Enchantra and the other wizards and witches until her baby is safety returned.
Enchantra turns Sabrina and Jessie from best friends to sworn enemies by hiding fighting sprites in their true friendship bracelets. Sabrina, being half-witch, manages to break free and now she must save Jessie before she hurts herself and their intense friendship.
The kids engage in a role-playing game in the woods. But the game soon becomes a reality after they unknowingly enter the magical world via a secret mystical portal hidden in a tree.
In order to recharge and further strengthen their magic wands, Sabrina and her friends are at the healing stone. However, an extremely powerful energy vortex created from increasingly believed human superstitions threatens to destroy all of Witch World.
Sabrina gets amnesia and is abducted by trolls, who is tricked into thinking she's a princess of trolls. Before long, the trolls use her powers to ambush witch school.
A real estate developer wants to demolish Sabrina's aunts' shop to create a parking lot for a new mall. Meanwhile Sabrina tries to stop the project with a scheme that gets out of hand.
Sabrina gets sick and and loses her powers. Meanwhile, the illness spreads to other witches and each loses their powers as well. Sabrina and Shinji go to the human world to find the source of the illness.
Sabrina gets trapped in Witch World to complete a test of the Journey of 10,000 steps. In the human world Sabrina's Aunt Hilda steps in to present her biology project.
