Peter starts Horizon High, a school for geniuses, the day that his best friend, Harry Osbourne, is suspended. Peter's debut as Spider-Man pits him against the Vulture.
Spidey and Miles welcomes The Octopus into the superhero club and patrol the streets with him. It quickly becomes apparent that The Octopus isn't a team player.
Peter goes to Oz Academy with Harry hoping to prove that Norman is out to destroy Spider-Man. The day is ruined when The Jackal invades with an army of Rhinos.
The spider-virus infects virtually all New Yorkers. Gwen and Spider-Man must help Black Widow track down Crossbones before he can deliver vibranium to Hydra.
After Gwen and Norman Osborn turn into spider monsters, Peter must find a way to cure the virus. Things get more complicated when Kraven the Hunter turns New York into his hunting grounds.
Peter and Harry must battle through an island of Spider-Monsters to get to Norman Osborn, who, appears to be controlling them all. The boys discover who the real mastermind is!
It takes a last ditch, desperate effort for Spider-Man, Kid Arachnic, Anya and Harry to save Manhattan from the spider-monsters that the Jackal has created.
