Michael Westen, a contract agent for various agencies including the CIA, finds that a burn notice has been issued for him. Stranded in Miami, he takes the case of a caretaker accused of stealing millions from his boss.
Weston is roped into helping his mother's friend get back money she lost in a scam, but Fi and Sam may ruin everything with their bumbling and bickering.
Michael's landlord, Oleg, is having a problem with one of his waitresses. She hasn't come into work because she witnessed a crime committed by a man who just happens to be a member of a local drug cartel. Michael is (mostly) happy to look into it, as he also continues his investigation into who stuck him with his burn notice.
Michael's brother is back in town, and he involves him in the search for a friend's daughter for less than pure motives. Elsewhere, an agent with a grudge comes after Michael.
Michael helps out an old SEAL buddy of Sam's who has gotten himself on the wrong side of a smuggler while trying to repossess his boat, and a new agent hits town set on making Michael's life miserable since he won't give up on finding his burn notice.
A slightly dim house sitter's fiancée has been kidnapped, and Sam guilts Michael into a rescue while he's negotiating with a D.C. bureaucrat to stop the burn notice.