Danger Mouse is fired by Colonel K after destroying the whole of London and bankrupting the Secret Service. He is immediately replaced by mechanical Safety Mice invented by the reformed Baron Silas Greenback.
Penfold insists on a mission free holiday, so DM agrees to go on a cruise. But Baron Greenback has made a machine that morphs ordinary sea creatures into terrifying sea monsters and holds the world ransom.
While Professor Squawkencluck is away at the Chicken's of Rock Festival, a small plant in her laboratory grows into a Vicious Scrub and engulfs the entire world because Danger Mouse insists on taking care of it.
Penfold accidentally drops an Aritificial Intelligence Quantum computer chip into a toilet at the Annual Conference of Genius Inventors. This causes it to come alive and start a revolting revolution.
A little girl called Dawn has won a competition to spend a day in Professor Squawkencluck's lab. After she and her teddy bear, Mr. Snuggles, fall into a vat of personality amplifying mind gel, Dawn is granted special powers to turn the world into one big pink dream house.
Fed up with Danger Mouse always breaking her gadgets, Professor Squawkencluck has invented HEAD (Headquarters Electronic Assault Defender) security system. But 'Big Head' soon starts to take over all security of Great Britain.
When Penfold disturbs the World Wide spiderweb that provides the Internet, the giant spider that constructed it becomes angry and attacks the Earth. Unfortunately, Danger Mouse has arachnophobia.
Red traffic lights pop up all around the world, stopping everyone and everything in their tracks. It's all part of Baron von Greenback's plan to stop the Earth spinning, causing everything to float into space due to a lack of gravity.
Greenback has stolen a Tectonic Plate Spinner from the U.S. government that can move an entire country to a different location with the touch of a button. Danger Mouse has to work together with his female American counterpart, Jeopardy Mouse.
Back in 1983 or thereabouts, Agent Danger K defeated Birch Badboy, who threatened to destroy the UK with his dreadfully rude behavior. Now, Badboy escapes from Arkwright Asylum, steals his megaphone from the top secret Danger Museum and attempts to complete his original plan, but this time expanded to include the entire world.
A colossal meteor is about to destroy the Earth. Professor Squawkencluck proposes to use her Schrinketizer invention to reduce the meteor in size. But the combination of Penfold's inability to catch and Isembard King Kong Brunel's determination to get his hands on the device causes disastrous results.
Danger Mouse's annual Danger Agent assessment day happens to coincide with a visit from the winner of the Danger Mouse fan competition: Ian, the greatest DM collector, ever.
Quark has transported Danger Mouse and Jeopardy Mouse (as well as Penfold) to another planet to compete against each other in the first ever trans-galactic battle show: Quark Games.
King Kong Brunel is using a time machine to make sure all of history's great inventions were never invented, so he can replace them with useless versions of his own design.
Professor Squawkencluck new Smart Cellery increases all the Danger Agent's intelligence, even Penfolds. But Baron Greenback counters it with his own 'Project Stupid'
Sinister Mouse, Danger Mouse's evil counterpart from the Twistyverse, is transported to the regular 'verse by Baron Greenback. Luckily, his arch enemy Danger Toad is not far behind.
Baron Greenback accidentally inhales his own mind-erasing gas. Danger Mouse takes the Baron to his original home, Greenback Village, to regain his memories before the rest of the gas is released.
DM is organizing a surprise birthday party for Professor Squawkencluck but Baron Greenback has booby-trapped all the presents, cards and birthday cakes and wants to wrap up the world for himself.
Big Head has been reprogrammed and renamed Big Head II. She captures all the world's criminals and imprisons them in a maximum security prison, then finds reasons to imprison all the Danger Agents as well.
Danger Sheep has disappeared trying to infiltrate Greenback's secret hideout. DM and Penfold are tasked to rescue him. But does Danger Sheep want saving from the Baron's luxurious island?
Cheesy villain Monsieur Aubrey le Camembert has stolen all the milk in the world to create a Dairy Death Ray and turn the world into cheese. Danger Mouse has to stop him with Baron Greenback cuffed to his wrist, after originally assuming the toad would be the culprit.
The Queen of Weevils is freed from her centuries long crystal prison by Danger Mouse because he doesn't believe in magic and proceeds to turn everyone and everything into gargoyles.
When Jeopardy Mouse is declared Agent of the Month, Danger Mouse is ordered to observe her actions and learn. He and Penfold get in the way of Jeopardy's fight against criminal organization Hydrant.
Penfold is addicted to posting selfies and spy mission status updates on social media site Spamchops, which gives Greenback info enough to be ahead of Danger Mouse at every turn.
Dawn, 'The Princess' uses an ancient Mayan calendar to get rid of all weekdays and make it permanently weekend. Now only Danger Mouse is on the job, as he likes to spend his weekends working anyway.
Squawkencluck is fired after Danger Mouse destroys her complete range of Danger vehicles. DM tries to get her reinstated by allowing Baron Greenback to cut the world in half using a Space Danger Laser.
Quark is factory producing Danger Mouse and Penfold clones so he can have them do heroic deeds and gain the trust of various valuable extra-terrestrial economies.
Various objects, including math tests and medals and even the moon, are being sucked into the Twystyverse by the evil Baron Silas Von Penfold who wants dominion over both worlds.
Penfold becomes a huge celebrity after winning 'Help, I'm a Hamster in the Jungle', then uses hypnotic glasses to urge his fans to destroy Danger Mouse.
DM goes undercover as the newest member of boy band All 4 It (now renamed All 5 It) to make sure the band's manager, Quark, has truly turned over a new leaf and become a legitimate businessman.
Quark has found a way to advertise his living furniture in people's dreams. Danger Mouse must follow Quark into Penfold's mind to stop the dream space-warehouse from crashing to Earth.
Elephant flu is infecting everybody in the world, transforming the entire population into elephants, except for Penfold who despises pachyderms because of a tragic incident.
The Queen of Weevils is transported to the Arkwright asylum but manages to infect DM with a Weevil that makes him hallucinate he's living in medieval times and needs to rescue a fair damsel.
Danger Mouse is assigned a new sidekick, the octopus Agent 58, but refuses to give up Penfold. Together they infiltrate Crimicon to stop King Kong Brunel's custard bomb.
Penfold is attending the annual Side-Kickie Awards and wants Danger Mouse out of the way so he won't embarrass him as usual. But Stilleto is intend on making sure he wins the main award himself.
Professor Ham Hands has unleashed an army of giant Hot Dog Monsters on London. Danger Mouse and Penfold go back to school to find, then stop the professor.
The Princess asks her daddy to destroy Danger Mouse, so he breaks her and 11 other villains from Arkwright Assylum to tire out DM before revealing himself to be his latest, greatest enemy.
Danger Mouse has been defeated by Augustus P. Crumhorn IV. Only Penfold refuses to give up hope that his beloved 'Chief' will still somehow return against all odds.
