During a burglary at Ten Downing Street, security system plans are copied and an African doll is taken as a decoy. While Lestrade seeks out the doll, Holmes and Watson are one step ahead in search of the secret plans.
Top Secret Global Intelligence information is stolen from Mark Trenton's safe. His superior Lord Bollinger calls in Sherlock Holmes, who finds Mark's wife desperate to help her husband.
After falling out over a woman, young scientists Victor Hatherley and Michael Wooden are working on developing blood regenerators separately. Fenwick leads a group of organ legging criminals and needs to get his hands on both well guarded devices.
Victor Trevor, a friend of Holmes, begins to receive cryptic messages from his father. The investigation uncovers new facts about a prisoner's high-jack of a lunar prison shuttle 25 years earlier.
Decorative crystals are being removed from the remaining few 'Napoleon Excelsior' luxury craft. The thief is after one particular crystal more valuable than both the vehicle and it's decorations.
Lestrade's college girlfriend Alice is getting married to Professor Jacob Presbury, father of another former schoolmate, Edith. Alice is being stalked by what seems to be a gorilla while Edith is convinced that Alice is after her inheritance.
Twelve year old Helphin-Payne the Third has invented a new processor, the Beryl Board. It is stolen from his business partner Alexander Holder's high security home, apparently by Holder's own son, Arthur. But Holmes finds there are many other suspects in this case.
Moriarty and Fenwick steal the Mazarin Chip, a voice activated virtual reality microchip that can create lifelike environments on demand, then kidnap the Prime Minister of England to crash the financial market from his secret hideout.
Lestrade is partnered with a rookie cop, Constable Abner Angel, against her will. Stange occurrences happen at New Scotland Yard when Lestrade and Holmes follow the trail of jewel thief Linus Beaumont.
