The King of France revenges himself on King Alfonso of Naples for the plague, and after finding pornographic frescoes the Pope decides to revive Roman bacchanalia.
Lucrezia is inconsolable after Paolo's death, but it is ruled a suicide as King Charles marches north to revenge themselves on the Pope and the Eternal City.
Cesare learns that Ursula and others at the convent have been slaughtered by the French, and he plans revenge as the Pope organizes a coalition to attack the retreating French.
A wounded Juan Borgia returns to Rome with lies about his bravery, and Lucrezia agrees to marry the son of a rich Genovese merchant but lusts after his brother.
The Pope excommunicates Friar Savanarola and he fails a test by fire while Giovanni haunted by shame and the agonies of syphilis threatens Lucrezia's son.
