In the exciting season opener, the surviving members of Mutant X emerge from a deadly explosion to meet the beautiful and mysterious Lexa, who makes them begin to question fundamental assumptions about their world.
A mutant who has the ability to inter phase with any computer with his mind, who is paralyzed after an encounter with the team, takes over Sanctuary's computers. Shalimar and Lexa get out, Jesse and Brennan are trapped and he tries to get them. The girls try to find out what's happening.
Mutant X unearths an old military experiment involving an age-reversal serum and is surprised to discover that Jesse's grandfather is a one of the test subjects.
Discovering that their teammate Lexa is the subject of a covert experiment that is controlling her, the Mutant X team hunts for the doctor responsible.
Lexa's suspicions lead Mutant X to unveil a traveling death camp, which is posed as a circus for mutant refugees and Mutant X's enemy within the Dominion.
Many of the mysteries surrounding Mutant X are revealed when Lexa and Jesse are captured by the Dominion and the team, along with Adam, goes in to rescue them.