Monk has stiff competition solving the case of a murdered jewelry store owner from a second-rate PI with a loser reputation who suddenly displays skills even more amazing than Monk's.
When Natalie finally catches up with the pizza guy who mistakenly left her $50 in change, she finds him dead in his car. She feels compelled to solve the murder but Monk, sick in bed, offers little help.
While on vacation for his anniversary, Mr. Monk chats with an intrusive but well-intentioned man at dinner. But when he wakes up the next day, everyone insists that the man was never there.
For the first time in years, Monk has made progress in therapy. But when Natalie discovers that Trudy may be alive, she risks unraveling her boss completely.
Natalie asks Randy to be her date to her brother's wedding. But when he's run down in the parking lot, Monk steps in to figure out what exactly is going on.
After a vicious truck stop attack, Monk awakens with amnesia in a desert hamlet, married to a domineering loon, and suspicious of the circumstances surrounding the hasty departure of a waitress.
Despite everyone's disbelief that a hero making the news is actually a coldblooded killer, Adrian tries to prove that a celebrity astronaut is responsible, despite an airtight alibi.
Monk must face his fear of dentists after Randy claims that he witnessed a murder while under sedation. The problem is that the case is connected to a recent armored car robbery.