The team becomes involved in a number of cases where people undergo dramatic mental aberrations that see them regress to their childhood. The team searches for a cure as well as a possible connection to a high profile murder case.
While Artie and Claudia investigate people turning into clay in Salt Lake City, Pete and a blonde Myke wake up together naked in Artie's bedroom and discover Steve missing.
As Steve and Claudia seek Ulysses S. Grant's flask within a Civil War re-enactment, Pete and Mika crash his ex-wife's wedding before a bee artifact gives everyone a hive mentality.
While artifact-hunting with Pete, Myka spots the man who killed her former partner and resolves to bring him in. Meanwhile, Artie mind-melds with a dog.
The Regents are under attack and several have been assassinated. It's up to the Warehosuse 13 crew to thwart the current attack by an unknown organization equipped with artifacts.
As Pete and Jane travel down Memory Lane, Myka and Claudia find a young woman at the center of several flash disappearances, all beyond sight of any artifact.
Frozen, flesh eating Zombies are running amok on a Campus in Ithaca, New York. Meanwhile, Death will stop at nothing to claim its next victim - Claudia.
It's nearly Christmas, and a brush with the upholstery brush of Philip Van Doren Stern bears Pete from his wonderful life into a world where he's never been born.