Warehouse 13 has been destroyed, Pandora's Box has been opened, and quite possibly the only hope left in the world lies in the use of a dangerous, evil artifact with the ability to turn back time.
Pete and Claudia reunite with Warehouse alumnus Hugo (Rene Auberjonois) to track down a deadly artifact at his nephew's prep school, while Myka and Steve investigate an Artifact that is killing an up and coming musician (Sam Huntington) in New Orleans.
Pete and Myka investigate a hockey player who seems to be miraculously and instantly recovering from serious game injuries, while Claudia is invited to a mysterious lunch by Mrs. Frederic. Elsewhere, Artie and Steve discover someone has been stealing artifacts from inside the Warehouse.
Someone has stolen Lewis Carroll's Mirror from inside the Warehouse allowing the psychotic and murderous spirit of Alice Liddell to escape again. Our team must stop her killing spree before one of them ends up dead.
Pete and Myka follow the trail of an artifact that seems to make people taller at first, only to cause them to get sick and die later. During the investigation, Pete gets involved with an attractive female drug company associate, who ends up suspecting Pete and Myka aren't just plain, average Secret Service agents. Meanwhile, Artie, Steve and Claudia follow up on the investigation of Brother Adrian and the missing artifacts.
Pete and Myka investigate the case of people literally rusting away in a West Virginia mill town. Steve and Claudia visit his hometown in New Jersey in a bid to end his dependence on the Metronome.
Pete, Myka, and Claudia each travel to save a loved one who has fallen victim to an artifact, Mrs. Frederic and Steve head to the Vatican to investigate the Brotherhood, and Artie has an impossible showdown with Brother Adrian.
H.G. Wells returns to help Pete and Myka with an artifact that's forcing confessions out of criminals all while earthquakes are beginning to shake the Warehouse.
When a volcanic event at an Arkansas State Prison allows two inmates to escape, Pete, Myka and Steve must partner with a U.S. Marshal to track down the fugitives.
The team tracks an evil alchemist who has bronzed Claudia and stolen the only artifact that can reverse the process. The clock is ticking as Claudia's condition apparently affects both Mrs. Frederic and the Warehouse.
The evil alchemist Paracelsus is on the run, and Pete and Myka must stop him before he achieves immortality - or something worse. Myka fights what appears to be a losing battle against cancer, while Steve learns Artie's been keeping life-altering information from Claudia.
