When Wanda's appendix ruptures with her parents out of town, Doogie ignores hospital policy to operate on her. This creates tension with Dr. Canfield as well as Wanda.
Fed up with being regarded as a 'nerd' by his peers and as a 'little kid' by his co-workers, Doogie decides to throw a party when his parents go away for the weekend.
After arguing with his dad about his finances, Doogie decides to go out on his own and rent an apartment. After hearing that a celebrity is staying at the hospital, Vinnie impersonates Doogie to meet her.
Frustrated with the strict policies, long shifts and stressful atmosphere of Eastman, Doogie gets a lucrative offer from a group of doctors from an upscale Brentwood hospital and seriously considers taking it.
The hospital agrees to let Vinnie film a documentary about Doogie. However, his annoying techniques and intrusive behavior annoy Doogie who must tell a family that their daughter might have cancer.
Doogie's busy schedule causes tension in his relationship with Wanda. He then sees an example of love-gone-wrong at the hospital when one of his patients needs a blood transfusion from his estranged wife who is unwilling to oblige unless he signs the divorce papers.
Doogie fixes Vinnie up with Wanda's cousin who is much larger than everyone expected. At the hospital, Doogie comes across a patient who is obsessed with her appearance.
Doogie's plans to go on a weekend getaway with Wanda are spoiled when he realizes that it's the same weekend as his dad's annual fishing trip. Not wanting to hurt his dad's feelings, he agrees to go.
Doogie and Wanda, feeling pressured to have sex, make plans to sleep together when Doogie's parents go away for the weekend. At the hospital, Doogie treats a 17-year old girl who gives birth and then abandons the baby on his doorstep.
Doogie, upset at the hospital's lack of compassion and adherence to a strict budget, decides to sneak in a dog with a broken leg and operate on it. When he gets caught, his job becomes at risk.
Doogie goes on a game-show for geniuses only to have everyone wanting a piece of the prizes. At the hospital, he treats an ex-boxer with symptoms of glaucoma.
Wanda gets upset after Doogie runs into an attractive former patient at the movie theater and he does nothing to resist her flirting. Doogie's parents stop talking to each other over the same issue.
When Doogie's mom mammogram reveals a lump on her breast that turns out to be benign, she decides that she is going to start living her life to the fullest, which includes singing at a nightclub.
As part of a community relations effort by the hospital, Doogie is asked to go to the high school and teach sexual education. On his first day, he is challenged to an after school fight by the captain of the football team.
In return for saving the life of the coolest guy in school, Doogie is rewarded by being allowed to hang around with him and his cool friends. With his newfound coolness, Doogie neglects Vinnie and disobeys his father.
When Doogie's dad begins to feel old and unimportant, he decides to quit his medical practice. Doogie and his mom then decide to gather many of the patients he has helped over the years in hopes of changing his mind.
Vinnie romances a blind girl that Doogie introduced him to at the hospital. When she gets an operation that will restore her sight, he worries that she will not find him physically attractive.
When Doogie and Jack hear a rumor that they are neck and neck for Resident of the Year, they both try to gain an advantage by trying to influence the judges which ultimately puts them in awkward positions.
Realizing that his relationship with Wanda has stalled, Doogie ponders whether to break it off or keep it going and risk being unhappy. Jack gets jealous when Curly begins dating a hotshot doctor.
Vinnie comes down with tonsillitis right before he is about to lose his virginity. Doogie is upset with Wanda when she tells him that she will be going away to France for the summer.
