After having an eerie dream where he is attacked by Frankenstein's Monster, Doogie goes to a psychiatrist and realizes that he is missing out on his life because of his job.
Doogie is surprised when Raymond, the former gang member who once held him hostage, shows up at the hospital. Impressed by Raymond's transformation into a responsible person, Doogie invites him to dinner and gets him a job at the hospital.
"Dr. Doogie" becomes an overnight sensation after he appears in public service announcements on a popular music channel. However, when his fame gets in the way of his job and normal life, he must choose whether he wants to keep up the hectic schedule.
While trying to talk his pregnant French teacher into helping him improve his failing grade, Vinnie ends up stuck in an elevator with her. She starts to go into labor and he is forced to call Doogie for help.
Doogie argues with his dad over whether he can buy a 1957 Chevy convertible. At the hospital, Doogie tries to get through to a mentally retarded patient who refuses treatment for a potentially fatal illness.
Doogie admits a homeless man to the hospital who turns out to be Blind Otis Lemon, a legendary blues player long thought to be dead. When Otis is scheduled for surgery to remove a tumor that could possibly leave him deaf, Vinnie and Raymond sneak him out of the hospital for one last gig.
One of the hospital benefactors, an elderly woman comes for her annual physical. Canfield informs Doogie that she's only generous unless she's told that something is wrong with her. So he tells Doogie to make something up.
Vinnie has problems finding someone to play a chainsaw killer in his slasher film. Doogie must spend time with an uptight 13-year old prodigy to determine if he is a good candidate for medical school.
Doogie is jealous when Wanda becomes friends with a male nude model in her art class. At the hospital, Doogie suspects that a pretty young model is bulimic. The hospital holds its annual bachelor auction with Doogie participating for the first time.
Vinnie is depressed when he learns that Janine's parents offered her a car if she would break up with him. Katherine's parents come to visit for Thanksgiving which causes tension with David who never felt they accepted him as their son-in-law.
After being dumped by McGuire, Curly starts dating the newly divorced Dr. Canfield. Doogie is chosen as one of five doctors to work with a highly-respected reconstructive surgeon.
Needing a recommendation to get into NYU film school, Vinnie poses as an orderly to try and meet the head of ABC television who is staying at the hospital. Meanwhile, Doogie's first poker night with the guys at the hospital is memorable for all the wrong reasons.
Doogie is attracted to a nursing student who he asks out behind Wanda's back. A man who is staying at the hospital is married to two different women without each one knowing about the other. He asks Doogie to try and prevent each one from seeing the other.
When Vinnie takes Doogie's car out for a spin, it gets smashed by a falling piano. Doogie, Vinnie, and Mrs. Howser agree not tell Dr. Howser who secretly finds out via a phone call from the auto mechanic. At the hospital, Doogie tries to order tests for a star college basketball player who refuses to seek treatment for fear that will damage his chances to play professionally.
Doogie, realizing that he has no athletic skills, fakes an injury so he doesn't have to play in an exhibition basketball game against a rival hospital. Raymond tries overly hard to impress a woman staying at the hospital, even though she has no interest in him.
The hospital hires an artist to decorate a mural inside the children's center. When it is found that the artist has AIDS, he is dismissed amid public concerns.
Katherine's parent make a surprise visit to the house while it is being remodeled. Her father quickly makes his presence known by offending the contractor who promptly quits on the spot. At the hospital, Doogie tells a couple with a family history of miscarriages that they're having a baby.
Still grieving over the death of her mother, Wanda has no time to go out with Doogie. She allows him to go to the hospital's annual Monte Carlo night with someone else. So Doogie asks a student nurse to go as his "date".
Doogie's mom takes a job as a patient advocate at the hospital. Doogie, upset because she is causing him embarrassment, and his dad, upset about not having dinner cooked, both think she should quit.
Jack comes back from a two-week trip in the Mexican rain forest as a changed man with the hospital no longer part of his plans. Doogie desperately scrambles to get a date for the Eastman dance.
Vinnie is nervous about possibly not getting accepted into film school. Doogie gets worried when the baby of a couple that has been trying to conceive for 12 years is born premature.
Vinnie and Janine convince Doogie to ask Wanda to the prom. At the hospital, Doogie is amazed by the positive attitude of a girl awaiting a heart transplant.
