Doogie and Vinnie move into an apartment. Doogie comes up with a risky solution to help a child with leukemia who has very few options for treatment and little time left.
Vinnie is upset and plans to do something stupid when Janine won't have sex with him, only to find out she has had sex. Little does he know the circumstances surrounding the loss of her virginity.
Planning to surprise Wanda in Chicago, things take a turn for Doogie when his car breaks down in the desert leading to an unexpected encounter that puts his situation into perspective.
Due to his extravagant spending, Doogie's father makes him pay rent to learn fiscal responsibility. Curly's father comes into the ER with heart difficulties. Doogie has a girl spend the night after she's too tired to drive home.
Wanda wants to be able to ask relationship advice from Doogie as a friend. They argue which turns into multiple phone conversation combinations between her, Doogie, Janine and Vinnie.
A patient with a 'ticking time bomb' in his head teaches Doogie about the value of truth, after Doogie asks out a co-worker after he's seen her medical records.
Vinnie and Doogie fight about the importance of their career choices when Vinnie ditches Doogie for his film classmates watching Jerry Lewis comedy instead of going to see the Bulls play. Later, Doogie uses The Three Stooges comedy to break through the tough shell of a young patient.
When Eastman receives a 3,000 year old mummy from a museum for study, Vinnie tries teaching Doogie about mummies from the old movies. Lights flicker as the mummy enters the CAT scan machine. It's an earthquake and rumors fly around the hospital.
The star actor from TV show LA Med wants to learn from Doogie how to be a more caring doctor; he's learned enough from 'old, cynical doctors'. Everyone's head is turned by the presence of the actor and the spotlight is off Doogie. Is it really jealousy he's feeling?
When Vinnie helps Doogie score some tickets to see Harry Connick, Jr., Doogie tells Cecelia he will pick her up at her place. She's says she'll meet him there. Vinnie thinks Cecelia is hiding something. Looks like a 4-year-old secret.
Vinnie makes a movie about himself for class. An elderly Czech patient keeps bugging Doogie for answers to trivia he can't remember to the point of belligerency.