A man is impaled in the mouth by a section of pipe after he runs through a chain link fence; A newlywed starts bleeding heavily inexplicably; Two prisoners are brought in. Are they lying or telling the truth.
A doctor's wife is admitted with what appears to be rectal bleeding; A man comes into the ER stuck to a camping stove; A six-year-old boy suffers a stroke.
A lock-down in the ER caused by a teacher who has brought in radioactive rocks causes complications as another patient needs to be moved into surgery for abdominal pains; A woman who is bleeding uncontrollably has to be driven across town to see a vascular surgeon; A drunk and stoned naked man is covered with cactus needles.
An ER doctor must perform an emergency room thoracotomy on a patient who has been stabbed in the chest; A man comes into the ER insisting on paying cash to have an object removed from his body; A young woman's family thinks she is possessed when she starts having seizures.
Doctors suspect an apparent child abuse victim might actually have a medical condition causing the injuries; A white German shepherd shows up in the ER on Halloween; A neurologist happens upon a motorcycle rider who has just wrecked.
A shooting victim's Rottweiler gets loose in the ER; A woman with a five-month-old baby is suffering from heart failure; A comatose man comes into the ER with a suspicious rash.
Doctors have to contend with a stroke victim's wife and two girlfriends; An understaffed medical clinic in Iraq has to tread three critical victims of an IED; A toddler's playful bite causes a rapidly spreading infection on the face of a recent liver transplant patient.
A doctor struggles with the decision to revive an older patient after prolonged CPR. Two nurses encounter a stabbing victim on the street and try to save him. A doctor on a cruise ship finds that her dream job has become a nightmare.